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Inhibition of follicular T-helper cells by CD8+ regulatory T cells is essential for self tolerance

Author

Listed:
  • Hye-Jung Kim

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Bert Verbinnen

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Xiaolei Tang

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Linrong Lu

    (Institute of Immunology, Zhejiang University, School of Medicine)

  • Harvey Cantor

    (Dana-Farber Cancer Institute
    Harvard Medical School)

Abstract

Role for CD8+ regulatory T cells in self-tolerance Analysis of the immune system has defined a subset of CD4+ T cells, termed CD4+ Treg, that can inhibit excessive inflammatory immune responses. However, no T cells genetically programmed to inhibit autoantibody formation and systemic-lupus-erythematosus-like disease have so far been defined. A mechanism fitting that description has now been identified in mice. A subset of CD8+ T cells (CD8+ Treg) is shown to prevent autoantibody formation and maintain self-tolerance in a process that involves recognition of Qa-1 peptide ligands expressed at the surface of follicular helper T cells. A detailed understanding of this aspect of immune-system regulation could lead to new approaches for the treatment of systemic lupus erythematosus and other autoimmune disorders.

Suggested Citation

  • Hye-Jung Kim & Bert Verbinnen & Xiaolei Tang & Linrong Lu & Harvey Cantor, 2010. "Inhibition of follicular T-helper cells by CD8+ regulatory T cells is essential for self tolerance," Nature, Nature, vol. 467(7313), pages 328-332, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7313:d:10.1038_nature09370
    DOI: 10.1038/nature09370
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