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Production of p53 gene knockout rats by homologous recombination in embryonic stem cells

Author

Listed:
  • Chang Tong

    (Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California)

  • Ping Li

    (Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California
    Present address: Key Laboratory of Molecular Medicine, Ministry of Education, Fudan University, Shanghai 200032, China.)

  • Nancy L. Wu

    (USC/Norris Cancer Center Transgenic/Knockout Core Facility, Keck School of Medicine, University of Southern California)

  • Youzhen Yan

    (USC/Norris Cancer Center Transgenic/Knockout Core Facility, Keck School of Medicine, University of Southern California)

  • Qi-Long Ying

    (Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California)

Abstract

On target for p53 knockout in the rat The rat is a widely used animal model for studying human physiology and disease, but functional genomics and genetic research have been stifled by the limited availability of gene-targeting tools. Qi-Long Ying and colleagues have now established gene targeting by homologous recombination in rat embryonic stem cells, and have generated for the first time p53 gene-knockout rats, suitable for physiological and pharmacological studies of the ubiquitous tumour suppressor p53.

Suggested Citation

  • Chang Tong & Ping Li & Nancy L. Wu & Youzhen Yan & Qi-Long Ying, 2010. "Production of p53 gene knockout rats by homologous recombination in embryonic stem cells," Nature, Nature, vol. 467(7312), pages 211-213, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7312:d:10.1038_nature09368
    DOI: 10.1038/nature09368
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