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Selectively tuning γ-secretase

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  • Peter St George-Hyslop

    (Peter St George-Hyslop is at the Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5S 3H2, Canada, and at the Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK. phs22@cam.ac.uk)

  • Gerold Schmitt-Ulms

    (Gerold Schmitt-Ulms is at the Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5S 3H2, Canada.)

Abstract

Presenilin proteins have a major role in normal cellular processes, but some contribute to disease, for example through the formation of amyloid-β. The way in which these different roles are regulated is now becoming clearer.

Suggested Citation

  • Peter St George-Hyslop & Gerold Schmitt-Ulms, 2010. "Selectively tuning γ-secretase," Nature, Nature, vol. 467(7311), pages 36-37, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7311:d:10.1038_467036a
    DOI: 10.1038/467036a
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