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IκBβ acts to inhibit and activate gene expression during the inflammatory response

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Listed:
  • Ping Rao

    (Yale University School of Medicine
    Present addresses: Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90033, USA (P.R.); Merck Research Laboratories, Boston, Massachusetts 02115, USA (M.L.S.); Center for Extracellular Matrix Biology, Texas A & M University Institute of Biosciences and Technology, Houston, Texas 77030, USA (D.Z.).)

  • Mathew S. Hayden

    (Yale University School of Medicine
    College of Physicians & Surgeons, Columbia University)

  • Meixiao Long

    (Yale University School of Medicine
    College of Physicians & Surgeons, Columbia University)

  • Martin L. Scott

    (California Institute of Technology
    Present addresses: Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90033, USA (P.R.); Merck Research Laboratories, Boston, Massachusetts 02115, USA (M.L.S.); Center for Extracellular Matrix Biology, Texas A & M University Institute of Biosciences and Technology, Houston, Texas 77030, USA (D.Z.).)

  • A. Philip West

    (Yale University School of Medicine)

  • Dekai Zhang

    (Yale University School of Medicine
    Present addresses: Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90033, USA (P.R.); Merck Research Laboratories, Boston, Massachusetts 02115, USA (M.L.S.); Center for Extracellular Matrix Biology, Texas A & M University Institute of Biosciences and Technology, Houston, Texas 77030, USA (D.Z.).)

  • Andrea Oeckinghaus

    (Yale University School of Medicine
    College of Physicians & Surgeons, Columbia University)

  • Candace Lynch

    (Signaling Systems Laboratory, University of California at San Diego)

  • Alexander Hoffmann

    (Signaling Systems Laboratory, University of California at San Diego)

  • David Baltimore

    (California Institute of Technology)

  • Sankar Ghosh

    (Yale University School of Medicine
    College of Physicians & Surgeons, Columbia University)

Abstract

IκBβ functions revealed The biological role of IκBβ, a major isoform of the IκB (inhibitor of nuclear factor-κB) family of proteins, has proved difficult to establish. Work on mice lacking IκBβ now shows that it serves a dual role, both inhibiting and facilitating the inflammatory response. IκBβ acts through p65:c-Rel dimers to maintain prolonged expression of TNFα. As a result, IκBβ−/− mice are resistant to LPS-induced septic shock and collagen-induced arthritis, and therefore blocking IκBβ might be a promising new strategy for selectively inhibiting the chronic phase of TNFα production during the inflammatory response.

Suggested Citation

  • Ping Rao & Mathew S. Hayden & Meixiao Long & Martin L. Scott & A. Philip West & Dekai Zhang & Andrea Oeckinghaus & Candace Lynch & Alexander Hoffmann & David Baltimore & Sankar Ghosh, 2010. "IκBβ acts to inhibit and activate gene expression during the inflammatory response," Nature, Nature, vol. 466(7310), pages 1115-1119, August.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7310:d:10.1038_nature09283
    DOI: 10.1038/nature09283
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