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Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells

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  • Paola Bonfanti

    (Laboratory of Stem Cell Dynamics, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
    Lausanne University Hospital (CHUV)
    Present address: Diabetes Research Center, Vrije Universiteit Brussel (VUB), B-1090 Brussel, Belgium.)

  • Stéphanie Claudinot

    (Laboratory of Stem Cell Dynamics, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
    Lausanne University Hospital (CHUV))

  • Alessandro W. Amici

    (Laboratory of Stem Cell Dynamics, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
    Lausanne University Hospital (CHUV))

  • Alison Farley

    (Institute for Stem Cell Research, MRC Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh)

  • C. Clare Blackburn

    (Institute for Stem Cell Research, MRC Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh)

  • Yann Barrandon

    (Laboratory of Stem Cell Dynamics, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
    Lausanne University Hospital (CHUV))

Abstract

Thymus cells reprogrammed The thymus serves a variety of functions in the adaptive immune system, including, through the thymic epithelial cells, the production of the self-tolerant thymocytes that develop into T lymphocytes. It has been widely assumed that the thymus contains only progenitor epithelial cells, with a limited repertoire of cell types. But work on rat thymic epithelial cells in cultures shows that, if exposed to the skin microenvironment, they can be reprogrammed to adopt the fate of hair-follicle multipotent stem cells. These cells can be cloned and extensively cultured, properties that are relevant to the possible growth of human thymic epithelial cells and potential clinical applications.

Suggested Citation

  • Paola Bonfanti & Stéphanie Claudinot & Alessandro W. Amici & Alison Farley & C. Clare Blackburn & Yann Barrandon, 2010. "Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells," Nature, Nature, vol. 466(7309), pages 978-982, August.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7309:d:10.1038_nature09269
    DOI: 10.1038/nature09269
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