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Diverse somatic mutation patterns and pathway alterations in human cancers

Author

Listed:
  • Zhengyan Kan

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
    Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Bijay S. Jaiswal

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Jeremy Stinson

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Vasantharajan Janakiraman

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Deepali Bhatt

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Howard M. Stern

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Peng Yue

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Peter M. Haverty

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Richard Bourgon

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Jianbiao Zheng

    (Affymetrix Inc, 3420 Central Expressway, Santa Clara, California 95051, USA)

  • Martin Moorhead

    (Affymetrix Inc, 3420 Central Expressway, Santa Clara, California 95051, USA)

  • Subhra Chaudhuri

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Lynn P. Tomsho

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab)

  • Brock A. Peters

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Kanan Pujara

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Shaun Cordes

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • David P. Davis

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Victoria E. H. Carlton

    (Affymetrix Inc, 3420 Central Expressway, Santa Clara, California 95051, USA)

  • Wenlin Yuan

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Li Li

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Weiru Wang

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Charles Eigenbrot

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Joshua S. Kaminker

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • David A. Eberhard

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Paul Waring

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Stephan C. Schuster

    (Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab)

  • Zora Modrusan

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Zemin Zhang

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • David Stokoe

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Frederic J. de Sauvage

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Malek Faham

    (Affymetrix Inc, 3420 Central Expressway, Santa Clara, California 95051, USA)

  • Somasekar Seshagiri

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

Abstract

Cancer-linked mutations A large-scale genetic analysis of more than 400 breast, lung, ovarian and prostate cancer samples has identified thousands of cancer-related mutations. Kan et al. analysed DNA from cancer patients and identified 2,576 somatic mutations across 1,507 coding genes. Of these, 77 are thought to be significantly mutated, implying possible pathogenic roles for protein kinases, G protein-coupled receptors and other potential therapeutic targets.

Suggested Citation

  • Zhengyan Kan & Bijay S. Jaiswal & Jeremy Stinson & Vasantharajan Janakiraman & Deepali Bhatt & Howard M. Stern & Peng Yue & Peter M. Haverty & Richard Bourgon & Jianbiao Zheng & Martin Moorhead & Subh, 2010. "Diverse somatic mutation patterns and pathway alterations in human cancers," Nature, Nature, vol. 466(7308), pages 869-873, August.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7308:d:10.1038_nature09208
    DOI: 10.1038/nature09208
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