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Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells

Author

Listed:
  • Jose L. Garcia-Perez

    (1241 East Catherine Street, University of Michigan Medical School
    Andalusian Stem Cell Bank, Consejeria de Salud Junta de Andalucia, Center for Biomedical Research, University of Granada)

  • Maria Morell

    (Andalusian Stem Cell Bank, Consejeria de Salud Junta de Andalucia, Center for Biomedical Research, University of Granada
    University of Michigan Medical School)

  • Joshua O. Scheys

    (Cellular and Molecular Biology Program, University of Michigan Medical School)

  • Deanna A. Kulpa

    (University of Michigan Medical School)

  • Santiago Morell

    (Andalusian Stem Cell Bank, Consejeria de Salud Junta de Andalucia, Center for Biomedical Research, University of Granada)

  • Christoph C. Carter

    (Cellular and Molecular Biology Program, University of Michigan Medical School)

  • Gary D. Hammer

    (University of Michigan Medical School
    Cellular and Molecular Biology Program, University of Michigan Medical School
    University of Michigan Medical School
    University of Michigan Medical School)

  • Kathleen L. Collins

    (Cellular and Molecular Biology Program, University of Michigan Medical School
    University of Michigan Medical School
    University of Michigan Medical School)

  • K. Sue O’Shea

    (University of Michigan Medical School)

  • Pablo Menendez

    (Andalusian Stem Cell Bank, Consejeria de Salud Junta de Andalucia, Center for Biomedical Research, University of Granada)

  • John V. Moran

    (1241 East Catherine Street, University of Michigan Medical School
    Cellular and Molecular Biology Program, University of Michigan Medical School
    University of Michigan Medical School
    Howard Hughes Medical Institute)

Abstract

Retrotransposons and genomic integrity The ability of retrotransposons to mobilize and insert into genes presents a challenge to a cell needing to maintain its genomic integrity. Garcia-Perez et al. have studied retrotransposition in embryonic carcinoma-derived cells. On insertion into the DNA, the retrotransposon is quickly silenced by a chromatin-dependent mechanism. However, this process is specific for certain retrotransposons, implying that multiple silencing mechanisms may exist. Once cells differentiate, the ability to silence newly introduced retrotransposons is lost, but previously inactivated retrotransposons remain inactive. This suggests that either a crucial silencing factor is not expressed in differentiated cells, or that a repressor of silencing is activated in differentiated cells.

Suggested Citation

  • Jose L. Garcia-Perez & Maria Morell & Joshua O. Scheys & Deanna A. Kulpa & Santiago Morell & Christoph C. Carter & Gary D. Hammer & Kathleen L. Collins & K. Sue O’Shea & Pablo Menendez & John V. Moran, 2010. "Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells," Nature, Nature, vol. 466(7307), pages 769-773, August.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7307:d:10.1038_nature09209
    DOI: 10.1038/nature09209
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