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New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism

Author

Listed:
  • Philipp Kapranov

    (Helicos BioSciences Corporation, 1 Kendall Sq. Ste B7301 Cambridge, Massachusetts 02139-1671, USA)

  • Fatih Ozsolak

    (Helicos BioSciences Corporation, 1 Kendall Sq. Ste B7301 Cambridge, Massachusetts 02139-1671, USA)

  • Sang Woo Kim

    (University of Pittsburgh School of Medicine)

  • Sylvain Foissac

    (Integromics, S.L., Grisolía 2, 28760 Tres Cantos, Madrid, Spain)

  • Doron Lipson

    (Helicos BioSciences Corporation, 1 Kendall Sq. Ste B7301 Cambridge, Massachusetts 02139-1671, USA)

  • Chris Hart

    (Helicos BioSciences Corporation, 1 Kendall Sq. Ste B7301 Cambridge, Massachusetts 02139-1671, USA)

  • Steve Roels

    (Helicos BioSciences Corporation, 1 Kendall Sq. Ste B7301 Cambridge, Massachusetts 02139-1671, USA)

  • Christelle Borel

    (University of Geneva Medical School, University of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland)

  • Stylianos E. Antonarakis

    (University of Geneva Medical School, University of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland)

  • A. Paula Monaghan

    (University of Pittsburgh)

  • Bino John

    (University of Pittsburgh School of Medicine)

  • Patrice M. Milos

    (Helicos BioSciences Corporation, 1 Kendall Sq. Ste B7301 Cambridge, Massachusetts 02139-1671, USA)

Abstract

Another clutch of small RNAs An analysis of short RNAs (with fewer than 200 nucleotides) from human cells using single molecule high-throughput sequencing has uncovered a previously unknown short RNA species with a difference. They all have the same 'tail' at their 5' ends, consisting of a sequence of non-genomically encoded polyU residues. This, together with the finding that these RNAs are closely associated with the 3' ends of known RNAs, points to the existence of a novel RNA-copying mechanism in human cells.

Suggested Citation

  • Philipp Kapranov & Fatih Ozsolak & Sang Woo Kim & Sylvain Foissac & Doron Lipson & Chris Hart & Steve Roels & Christelle Borel & Stylianos E. Antonarakis & A. Paula Monaghan & Bino John & Patrice M. M, 2010. "New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism," Nature, Nature, vol. 466(7306), pages 642-646, July.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7306:d:10.1038_nature09190
    DOI: 10.1038/nature09190
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