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Segregation of yeast nuclear pores

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  • Anton Khmelinskii

    (* Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany. e.schiebel@zmbh.uni-heidelberg.de)

  • Philipp J. Keller

    († European Molecular Biology Laboratory (EMBL), Cell Biology and Biophysics Unit, Meyerhofstr. 1, D-69117 Heidelberg, Germany. knop@embl.de)

  • Holger Lorenz

    (* Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany. e.schiebel@zmbh.uni-heidelberg.de)

  • Elmar Schiebel

    (* Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany. e.schiebel@zmbh.uni-heidelberg.de)

  • Michael Knop

    († European Molecular Biology Laboratory (EMBL), Cell Biology and Biophysics Unit, Meyerhofstr. 1, D-69117 Heidelberg, Germany. knop@embl.de)

Abstract

Arising from: Z. Shcheprova, S. Baldi, S. B. Frei, G. Gonnet & Y. Barral Nature 454, 728–734 (2008)10.1038/nature07212 During mitosis in Saccharomyces cerevisiae, senescence factors such as extrachromosomal ribosomal DNA circles (ERCs) are retained in the mother cell and excluded from the bud/daughter cell1. Shcheprova et al.2 proposed a model suggesting segregation of ERCs through their association with nuclear pore complexes (NPCs) and retention of pre-existing NPCs in the mother cell during mitosis. However, this model is inconsistent with previous data3 and we demonstrate here that NPCs do efficiently migrate from the mother into the bud. Therefore, binding to NPCs does not seem to explain the retention of ERCs in the mother cell.

Suggested Citation

  • Anton Khmelinskii & Philipp J. Keller & Holger Lorenz & Elmar Schiebel & Michael Knop, 2010. "Segregation of yeast nuclear pores," Nature, Nature, vol. 466(7305), pages 1-1, July.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7305:d:10.1038_nature09255
    DOI: 10.1038/nature09255
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