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Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning

Author

Listed:
  • Hai Song

    (Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA)

  • Jianxin Hu

    (Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA)

  • Wen Chen

    (Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA)

  • Gene Elliott

    (Transgenic Mouse Core, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA)

  • Philipp Andre

    (Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA)

  • Bo Gao

    (Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA)

  • Yingzi Yang

    (Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA)

Abstract

Body line decisions The three animal body axes are established sequentially during development — first the anteroposterior and dorsoventral axes, and then left–right asymmetry — but how the latter derives from the former has been unclear. Now, Yingzi Yang and colleagues show that two mouse genes belonging to the 'planar cell polarity' family (Vangl1 and Vangl2) are required for the posterior deposition of cilia, which in turn determines the leftward nodal flow across the posterior notochord. This work suggests that planar cell polarity is an evolutionarily conserved mechanism that transmits the predetermined anteroposterior positional information and converts it to the first lateral symmetry-breaking event in the embryo.

Suggested Citation

  • Hai Song & Jianxin Hu & Wen Chen & Gene Elliott & Philipp Andre & Bo Gao & Yingzi Yang, 2010. "Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning," Nature, Nature, vol. 466(7304), pages 378-382, July.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7304:d:10.1038_nature09129
    DOI: 10.1038/nature09129
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