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Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b

Author

Listed:
  • Lei Zeng

    (Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1677, New York, New York 10029, USA)

  • Qiang Zhang

    (Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1677, New York, New York 10029, USA)

  • SiDe Li

    (Mount Sinai School of Medicine)

  • Alexander N. Plotnikov

    (Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1677, New York, New York 10029, USA)

  • Martin J. Walsh

    (Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1677, New York, New York 10029, USA
    Mount Sinai School of Medicine)

  • Ming-Ming Zhou

    (Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1677, New York, New York 10029, USA)

Abstract

Reading histone acetylation Histone lysine acetylation or methylation helps to regulate chromatin functions during gene transcription. Histone acetylation marks are typically recognized by proteins containing bromodomains, but recently, an alternative mechanism of acetyl-lysine binding was recognized in the tandem plant homeodomain (PHD) finger of human DPF3b, a protein that functions in gene activation. The three-dimensional solution structures of DPF3b bound to a lysine 14-acetylated histone H3 peptide have now been determined, offering mechanistic insight into the way the protein recognizes acetylation marks.

Suggested Citation

  • Lei Zeng & Qiang Zhang & SiDe Li & Alexander N. Plotnikov & Martin J. Walsh & Ming-Ming Zhou, 2010. "Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b," Nature, Nature, vol. 466(7303), pages 258-262, July.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7303:d:10.1038_nature09139
    DOI: 10.1038/nature09139
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    1. Huanhuan Cui & Hongyang Yi & Hongyu Bao & Ying Tan & Chi Tian & Xinyao Shi & Diwen Gan & Bin Zhang & Weizheng Liang & Rui Chen & Qionghua Zhu & Liang Fang & Xin Gao & Hongda Huang & Ruijun Tian & Silk, 2022. "The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Lunying Wu & Xiaohui Jing & Baolan Zhang & Shoujun Chen & Ran Xu & Penggen Duan & Danni Zou & Shengjian Huang & Tingbo Zhou & Chengcai An & Yuehua Luo & Yunhai Li, 2022. "A natural allele of OsMS1 responds to temperature changes and confers thermosensitive genic male sterility," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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