IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v465y2010i7301d10.1038_nature09128.html
   My bibliography  Save this article

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

Author

Listed:
  • Sergio E. Alvarez

    (Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, Virginia 23298, USA
    Present address: IMIBIO-SL CONICET, Ejército de los Andes 950, San Luis 5700, Argentina.)

  • Kuzhuvelil B. Harikumar

    (Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, Virginia 23298, USA)

  • Nitai C. Hait

    (Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, Virginia 23298, USA)

  • Jeremy Allegood

    (Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, Virginia 23298, USA)

  • Graham M. Strub

    (Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, Virginia 23298, USA)

  • Eugene Y. Kim

    (Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, Virginia 23298, USA)

  • Michael Maceyka

    (Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, Virginia 23298, USA)

  • Hualiang Jiang

    (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences)

  • Cheng Luo

    (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences)

  • Tomasz Kordula

    (Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, Virginia 23298, USA)

  • Sheldon Milstien

    (Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, Virginia 23298, USA)

  • Sarah Spiegel

    (Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, Virginia 23298, USA)

Abstract

A cofactor for the E3 ubiquitin ligase TRAF2 TRAF2 (tumour-necrosis factor receptor-associated factor 2), a component of the NF-κB activation pathway important in inflammatory, anti-apoptotic, and immune processes, is shown to be a target of sphingosine kinase 1, one of the isoenzymes that generates the pro-survival lipid mediator sphingosine-1-phosphate inside cells. In addition, sphingosine kinase 1 is revealed as the 'missing' cofactor for TRAF2 E3 ubiquitin ligase activity. These findings provide a mechanistic explanation for the numerous observations of the importance of SphK1 in inflammatory, anti-apoptotic and immune processes.

Suggested Citation

  • Sergio E. Alvarez & Kuzhuvelil B. Harikumar & Nitai C. Hait & Jeremy Allegood & Graham M. Strub & Eugene Y. Kim & Michael Maceyka & Hualiang Jiang & Cheng Luo & Tomasz Kordula & Sheldon Milstien & Sar, 2010. "Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2," Nature, Nature, vol. 465(7301), pages 1084-1088, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7301:d:10.1038_nature09128
    DOI: 10.1038/nature09128
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09128
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09128?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:465:y:2010:i:7301:d:10.1038_nature09128. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.