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Activation of autophagy during cell death requires the engulfment receptor Draper

Author

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  • Christina K. McPhee

    (University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    University of Maryland, College Park, Maryland 20742, USA)

  • Mary A. Logan

    (University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA)

  • Marc R. Freeman

    (University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA)

  • Eric H. Baehrecke

    (University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA)

Abstract

Draper protein regulates autophagy during cell death Autophagy, the process by which a cell digests its own components in the lysosomes, is an ancient and well-conserved pathway that acts as a survival response to starvation but has also been associated with cell death. In this study, McPhee et al. identify the first factor that regulates autophagy during cell death, but not during cell survival. They find that in Drosophila, the engulfment receptor Draper is a critical regulator of autophagy during cell death of Drosophila salivary glands but is not required for starvation-induced autophagy during fat body cell survival. This is the first example of an engulfment factor that is autonomously required for self-clearance.

Suggested Citation

  • Christina K. McPhee & Mary A. Logan & Marc R. Freeman & Eric H. Baehrecke, 2010. "Activation of autophagy during cell death requires the engulfment receptor Draper," Nature, Nature, vol. 465(7301), pages 1093-1096, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7301:d:10.1038_nature09127
    DOI: 10.1038/nature09127
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