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Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription

Author

Listed:
  • Shouhong Guang

    (Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA)

  • Aaron F. Bochner

    (Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA)

  • Kirk B. Burkhart

    (Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA)

  • Nick Burton

    (Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA)

  • Derek M. Pavelec

    (University of Wisconsin, Madison, Wisconsin 53706, USA)

  • Scott Kennedy

    (Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
    University of Wisconsin, Madison, Wisconsin 53706, USA)

Abstract

NRDE-2 active in transcription regulation Small RNAs function in both the cytoplasm, inhibiting expression from messenger RNAs, and in the nucleus, to silence heterochromatin and prevent genome rearrangement. In this study, Guang et al. characterize a new protein involved in RNA interference in the nucleus. NRDE-2 associates with the Argonaute protein NRDE-3 and siRNAs on nascent transcripts. This association prevents elongation by RNA polymerase II, thereby making this a co-transcriptional form of gene silencing.

Suggested Citation

  • Shouhong Guang & Aaron F. Bochner & Kirk B. Burkhart & Nick Burton & Derek M. Pavelec & Scott Kennedy, 2010. "Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription," Nature, Nature, vol. 465(7301), pages 1097-1101, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7301:d:10.1038_nature09095
    DOI: 10.1038/nature09095
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    Cited by:

    1. Shihui Chen & Carolyn M. Phillips, 2024. "HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Maxim V. Zagoskin & Jianbin Wang & Ashley T. Neff & Giovana M. B. Veronezi & Richard E. Davis, 2022. "Small RNA pathways in the nematode Ascaris in the absence of piRNAs," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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