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Human adult germline stem cells in question

Author

Listed:
  • Kinarm Ko

    (Max Planck Institute for Molecular Biomedicine)

  • Marcos J. Araúzo-Bravo

    (Max Planck Institute for Molecular Biomedicine)

  • Natalia Tapia

    (Max Planck Institute for Molecular Biomedicine)

  • Julee Kim

    (Max Planck Institute for Molecular Biomedicine)

  • Qiong Lin

    (Institute for Biomedical Engineering, RWTH Aachen University Medical School
    Helmholtz Institute for Biomedical Engineering, RWTH Aachen University)

  • Christof Bernemann

    (Max Planck Institute for Molecular Biomedicine)

  • Dong Wook Han

    (Max Planck Institute for Molecular Biomedicine)

  • Luca Gentile

    (Max Planck Institute for Molecular Biomedicine)

  • Peter Reinhardt

    (Max Planck Institute for Molecular Biomedicine)

  • Boris Greber

    (Max Planck Institute for Molecular Biomedicine)

  • Rebekka K. Schneider

    (Institute for Biomedical Engineering, RWTH Aachen University Medical School
    Helmholtz Institute for Biomedical Engineering, RWTH Aachen University)

  • Sabine Kliesch

    (Centre for Reproductive Medicine and Andrology, University of Münster)

  • Martin Zenke

    (Institute for Biomedical Engineering, RWTH Aachen University Medical School
    Helmholtz Institute for Biomedical Engineering, RWTH Aachen University)

  • Hans R. Schöler

    (Max Planck Institute for Molecular Biomedicine
    Faculty of Medicine, University of Münster)

Abstract

Arising from: S. Conrad et al. Nature 456, 344–349 (2008)10.1038/nature07404 ; Conrad et al. reply Conrad et al. have generated human adult germline stem cells (haGSCs) from human testicular tissue, which they claim have similar pluripotent properties to human embryonic stem cells (hESCs)1. Here we investigate the pluripotency of haGSCs by using global gene-expression analysis based on their gene array data1 and comparing the expression of pluripotency marker genes in haGSCs and hESCs, and in haGSCs and human fibroblast samples derived from different laboratories, including our own. We find that haGSCs and fibroblasts have a similar gene-expression profile, but that haGSCs and hESCs do not. The pluripotency of Conrad and colleagues’ haGSCs is therefore called into question.

Suggested Citation

  • Kinarm Ko & Marcos J. Araúzo-Bravo & Natalia Tapia & Julee Kim & Qiong Lin & Christof Bernemann & Dong Wook Han & Luca Gentile & Peter Reinhardt & Boris Greber & Rebekka K. Schneider & Sabine Kliesch , 2010. "Human adult germline stem cells in question," Nature, Nature, vol. 465(7301), pages 1-1, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7301:d:10.1038_nature09089
    DOI: 10.1038/nature09089
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