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TFIIA and the transactivator Rap1 cooperate to commit TFIID for transcription initiation

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  • Gabor Papai

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 1 rue Laurent Fries, BP10142, 67404 Illkirch, France
    U964, Inserm, Illkirch, F-67400 France
    UMR7104, CNRS, Illkirch, F-67400 France
    Université de Strasbourg, Strasbourg, F-67000, France)

  • Manish K. Tripathi

    (Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA)

  • Christine Ruhlmann

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 1 rue Laurent Fries, BP10142, 67404 Illkirch, France
    U964, Inserm, Illkirch, F-67400 France
    UMR7104, CNRS, Illkirch, F-67400 France
    Université de Strasbourg, Strasbourg, F-67000, France)

  • Justin H. Layer

    (Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA)

  • P. Anthony Weil

    (Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA)

  • Patrick Schultz

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 1 rue Laurent Fries, BP10142, 67404 Illkirch, France
    U964, Inserm, Illkirch, F-67400 France
    UMR7104, CNRS, Illkirch, F-67400 France
    Université de Strasbourg, Strasbourg, F-67000, France)

Abstract

Early steps in transcription initiation The early steps of activator-dependent transcription in yeast are examined by determining the cryo-EM structures of the transcription activator Rap1 complexed to general transcription factors TFIID and TFIIA and yeast enhancer–promoter DNA. A model is proposed whereby interactions between Rap1 and TFIIA convey activating signals to TFIID, and a Rap1-dependent DNA loop is visualized between the enhancer and the promoter.

Suggested Citation

  • Gabor Papai & Manish K. Tripathi & Christine Ruhlmann & Justin H. Layer & P. Anthony Weil & Patrick Schultz, 2010. "TFIIA and the transactivator Rap1 cooperate to commit TFIID for transcription initiation," Nature, Nature, vol. 465(7300), pages 956-960, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7300:d:10.1038_nature09080
    DOI: 10.1038/nature09080
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