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Extrinsic regulation of pluripotent stem cells

Author

Listed:
  • Martin F. Pera

    (Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California)

  • Patrick P. L. Tam

    (Embryology Unit, Children's Medical Research Institute
    Discipline of Medicine, Sydney Medical School, University of Sydney)

Abstract

During early mammalian development, as the pluripotent cells that give rise to all of the tissues of the body proliferate and expand in number, they pass through transition states marked by a stepwise restriction in developmental potential and by changes in the expression of key regulatory genes. Recent findings show that cultured stem-cell lines derived from different stages of mouse development can mimic these transition states. They further reveal that there is a high degree of heterogeneity and plasticity in pluripotent populations in vitro and that these properties are modulated by extrinsic signalling. Understanding the extrinsic control of plasticity will guide efforts to use human pluripotent stem cells in research and therapy.

Suggested Citation

  • Martin F. Pera & Patrick P. L. Tam, 2010. "Extrinsic regulation of pluripotent stem cells," Nature, Nature, vol. 465(7299), pages 713-720, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7299:d:10.1038_nature09228
    DOI: 10.1038/nature09228
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