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CD95 promotes tumour growth

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  • Lina Chen

    (The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA
    Present addresses: Osaka University Graduate School of Medicine, Department of Obstetrics & Gynecology, 2-2, Yamadaoka, Suita, Osaka 565-0879, Japan (K.S.); Cambridge Research Institute/Cancer Research UK, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK (C.F.); Northwestern University Feinberg School of Medicine, 303 East Superior Street, Chicago, Illinois 60611, USA (L.C., A.H. and M.E.P.).)

  • Sun-Mi Park

    (The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA)

  • Alexei V. Tumanov

    (The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA)

  • Annika Hau

    (The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA
    Present addresses: Osaka University Graduate School of Medicine, Department of Obstetrics & Gynecology, 2-2, Yamadaoka, Suita, Osaka 565-0879, Japan (K.S.); Cambridge Research Institute/Cancer Research UK, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK (C.F.); Northwestern University Feinberg School of Medicine, 303 East Superior Street, Chicago, Illinois 60611, USA (L.C., A.H. and M.E.P.).)

  • Kenjiro Sawada

    (The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA
    Present addresses: Osaka University Graduate School of Medicine, Department of Obstetrics & Gynecology, 2-2, Yamadaoka, Suita, Osaka 565-0879, Japan (K.S.); Cambridge Research Institute/Cancer Research UK, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK (C.F.); Northwestern University Feinberg School of Medicine, 303 East Superior Street, Chicago, Illinois 60611, USA (L.C., A.H. and M.E.P.).)

  • Christine Feig

    (The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA
    Present addresses: Osaka University Graduate School of Medicine, Department of Obstetrics & Gynecology, 2-2, Yamadaoka, Suita, Osaka 565-0879, Japan (K.S.); Cambridge Research Institute/Cancer Research UK, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK (C.F.); Northwestern University Feinberg School of Medicine, 303 East Superior Street, Chicago, Illinois 60611, USA (L.C., A.H. and M.E.P.).)

  • Jerrold R. Turner

    (The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA)

  • Yang-Xin Fu

    (The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA)

  • Iris L. Romero

    (The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA)

  • Ernst Lengyel

    (The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA)

  • Marcus E. Peter

    (The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA
    Present addresses: Osaka University Graduate School of Medicine, Department of Obstetrics & Gynecology, 2-2, Yamadaoka, Suita, Osaka 565-0879, Japan (K.S.); Cambridge Research Institute/Cancer Research UK, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK (C.F.); Northwestern University Feinberg School of Medicine, 303 East Superior Street, Chicago, Illinois 60611, USA (L.C., A.H. and M.E.P.).)

Abstract

CD95/Fas promotes tumour growth CD95, known also as Fas and APO-1, is a classical death receptor that regulates tissue homeostasis through apoptosis. Here it is shown that cancer cells, regardless of their sensitivity to CD95-induced apoptosis, depend for optimal growth on CD95. Without CD95 the incidence of ovarian cancer and liver cancer in mice models is reduced, as is their tumour size. CD95 therefore appears to be a double-edged sword: in order to kill tumour cells it may be necessary to reduce, rather than enhance, CD95 activity.

Suggested Citation

  • Lina Chen & Sun-Mi Park & Alexei V. Tumanov & Annika Hau & Kenjiro Sawada & Christine Feig & Jerrold R. Turner & Yang-Xin Fu & Iris L. Romero & Ernst Lengyel & Marcus E. Peter, 2010. "CD95 promotes tumour growth," Nature, Nature, vol. 465(7297), pages 492-496, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7297:d:10.1038_nature09075
    DOI: 10.1038/nature09075
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