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Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization

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  • Carson K. Lam

    (Northwestern University Feinberg School of Medicine, Chicago, Ilinois 60611 USA)

  • Taehwan Yoo

    (Northwestern University Feinberg School of Medicine, Chicago, Ilinois 60611 USA)

  • Bennett Hiner

    (Northwestern University Feinberg School of Medicine, Chicago, Ilinois 60611 USA)

  • Zhiqiang Liu

    (Northwestern University Feinberg School of Medicine, Chicago, Ilinois 60611 USA)

  • Jaime Grutzendler

    (Northwestern University Feinberg School of Medicine, Chicago, Ilinois 60611 USA
    Physiology, Northwestern University Feinberg School of Medicine, Chicago, Ilinois 60611, USA)

Abstract

Cerebral blood flow: grab and flow Throughout our lives, tiny blood clots or microemboli develop in the blood vessels of the brain. Many are removed by the force of the blood flow and others are digested by fibrinolysis. Now a third embolus removal mechanism has been discovered: embolus extravasation. High-resolution fixed tissue microscopy and two-photon imaging in live mice shows that many microemboli are not lysed by blood or fibrinolysis, but are instead actively removed within a week by endothelial cells that envelop the emboli, as the underlying endothelium is remodelled to produce an unblocked blood vessel. This process takes longer in aged mice, suggesting that clot-clearance is a possible therapeutic target in patients recovering from a stroke or for age-related cognitive disorders.

Suggested Citation

  • Carson K. Lam & Taehwan Yoo & Bennett Hiner & Zhiqiang Liu & Jaime Grutzendler, 2010. "Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization," Nature, Nature, vol. 465(7297), pages 478-482, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7297:d:10.1038_nature09001
    DOI: 10.1038/nature09001
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