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Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

Author

Listed:
  • Andrej Košmrlj

    (Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

  • Elizabeth L. Read

    (Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

  • Ying Qi

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA)

  • Todd M. Allen

    (Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA)

  • Marcus Altfeld

    (Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA)

  • Steven G. Deeks

    (University of California, San Francisco, California 94110, USA)

  • Florencia Pereyra

    (Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA)

  • Mary Carrington

    (Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA)

  • Bruce D. Walker

    (Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA)

  • Arup K. Chakraborty

    (Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts 02114, USA
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

Abstract

Resisting HIV infection Certain HIV-infected individuals, termed 'elite controllers', maintain extremely low viral loads over long time periods without therapy. A number of HLA class I alleles are enriched in these individuals, most prominently HLA-B57. The paper provides a model of how elite controllers might generate an effective immune response against HIV. According to the model, HLA-B57 binds fewer self-peptides, resulting in a T-cell repertoire with enhanced cross-reactivity and leading to a more effective T-cell response against the virus. This work may have implications for vaccination strategies.

Suggested Citation

  • Andrej Košmrlj & Elizabeth L. Read & Ying Qi & Todd M. Allen & Marcus Altfeld & Steven G. Deeks & Florencia Pereyra & Mary Carrington & Bruce D. Walker & Arup K. Chakraborty, 2010. "Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection," Nature, Nature, vol. 465(7296), pages 350-354, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7296:d:10.1038_nature08997
    DOI: 10.1038/nature08997
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