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Modulation of Shigella virulence in response to available oxygen in vivo

Author

Listed:
  • Benoit Marteyn

    (Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London)

  • Nicholas P. West

    (Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London
    Present address: Centenary Institute, Newtown, New South Wales 2042, Australia.)

  • Douglas F. Browning

    (School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK)

  • Jeffery A. Cole

    (School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK)

  • Jonathan G. Shaw

    (University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK)

  • Fredrik Palm

    (Biomedical Center, Uppsala University)

  • Joelle Mounier

    (Unité de Pathogénie Microbienne Moléculaire, and Unité INSERM786, Institut Pasteur, 28 rue du Dr Roux, F-75724 Paris Cédex 15, France)

  • Marie-Christine Prévost

    (Plateforme de Microscopie électronique, Institut Pasteur, 25 Rue du Docteur Roux, F-75724 Paris cedex 15, France)

  • Philippe Sansonetti

    (Unité de Pathogénie Microbienne Moléculaire, and Unité INSERM786, Institut Pasteur, 28 rue du Dr Roux, F-75724 Paris Cédex 15, France
    Collège de France, 11 Place Marcelin Berthelot, F-75231, Paris Cédex 05, France)

  • Christoph M. Tang

    (Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London)

Abstract

Oxygen and Shigella flexneri virulence Shigella flexneri, a bacterial dysentery pathogen, employs a type III secretion system to inject virulence factors into host cells during enteric infection. It is now suggested that oxygen availability during different phases of infection tightly regulates expression of the secretion system as well as the secretion of virulence factors.

Suggested Citation

  • Benoit Marteyn & Nicholas P. West & Douglas F. Browning & Jeffery A. Cole & Jonathan G. Shaw & Fredrik Palm & Joelle Mounier & Marie-Christine Prévost & Philippe Sansonetti & Christoph M. Tang, 2010. "Modulation of Shigella virulence in response to available oxygen in vivo," Nature, Nature, vol. 465(7296), pages 355-358, May.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7296:d:10.1038_nature08970
    DOI: 10.1038/nature08970
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