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Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling

Author

Listed:
  • Pietro Fazzari

    (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández)

  • Ana V. Paternain

    (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández)

  • Manuel Valiente

    (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández)

  • Ramón Pla

    (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández)

  • Rafael Luján

    (Facultad de Medicina, Universidad de Castilla-La Mancha)

  • Kent Lloyd

    (California National Primate Research Center, University of California, Davis, California 95616, USA)

  • Juan Lerma

    (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández)

  • Oscar Marín

    (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández)

  • Beatriz Rico

    (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández)

Abstract

Inhibitory synapses: making connections Although several synaptic adhesion proteins have been identified as genetic risk factors in schizophrenia, it is unclear what role they may play in disease progression. A new study suggests that Neuregulin-1 (Nrg1) and its receptor ErbB4 function to regulate the connectivity of specific inhibitory cortical circuits. With so little known about how inhibitory synapses are made, this study provides important evidence implicating Nrg1/ErbB4 signalling in this process, as well as providing a perspective on how these genes may be involved in the onset of schizophrenia.

Suggested Citation

  • Pietro Fazzari & Ana V. Paternain & Manuel Valiente & Ramón Pla & Rafael Luján & Kent Lloyd & Juan Lerma & Oscar Marín & Beatriz Rico, 2010. "Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling," Nature, Nature, vol. 464(7293), pages 1376-1380, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7293:d:10.1038_nature08928
    DOI: 10.1038/nature08928
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