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Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends

Author

Listed:
  • Steven A. Roberts

    (Lineberger Comprehensive Cancer Center, and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA)

  • Natasha Strande

    (Lineberger Comprehensive Cancer Center, and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA)

  • Martin D. Burkhalter

    (Lineberger Comprehensive Cancer Center, and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA)

  • Christina Strom

    (Lineberger Comprehensive Cancer Center, and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA)

  • Jody M. Havener

    (Lineberger Comprehensive Cancer Center, and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA)

  • Paul Hasty

    (The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245, USA)

  • Dale A. Ramsden

    (Lineberger Comprehensive Cancer Center, and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA)

Abstract

End-to-end DNA repair Most agents that generate breaks in DNA leave 'dirty ends' that cannot reunite without some intervening steps to restore the integrity of the nucleotides at the break. In this work, Roberts et al. show that the non-homologous end joining (NHEJ) repair pathway requires a 5′-dRP/AP lyase activity to remove abasic sites. Surprisingly, this activity is catalysed by Ku70, which, with its partner Ku86, had previously been thought only to recognize broken DNA ends and to recruit other NHEJ proteins to that site.

Suggested Citation

  • Steven A. Roberts & Natasha Strande & Martin D. Burkhalter & Christina Strom & Jody M. Havener & Paul Hasty & Dale A. Ramsden, 2010. "Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends," Nature, Nature, vol. 464(7292), pages 1214-1217, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7292:d:10.1038_nature08926
    DOI: 10.1038/nature08926
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