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MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis

Author

Listed:
  • Stefania Nicoli

    (Program in Gene Function and Expression,)

  • Clive Standley

    (Biomedical Imaging Group, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA)

  • Paul Walker

    (Molecular Cancer Studies Group, Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK)

  • Adam Hurlstone

    (Molecular Cancer Studies Group, Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK)

  • Kevin E. Fogarty

    (Biomedical Imaging Group, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA)

  • Nathan D. Lawson

    (Program in Gene Function and Expression,)

Abstract

Angiogenesis: grow with the flow During embryogenesis, blood vessels are remodelled in response to blood flow. Nicoli et al. describe a genetic pathway that explains how this mechanosensory stimulus is integrated with early developmental signals to remodel aortic arch vessels in zebrafish. The flow-induced transcription factor klf2a is required for the induction of an endothelial cell-specific microRNA, miR-126, which promotes VEGF signalling and angiogenesis through repressing Spred1, an inhibitor of VEGF signalling. This demonstrates how blood flow modulates endothelial cell-signalling pathways and implicates a microRNA as a central integration point during this process.

Suggested Citation

  • Stefania Nicoli & Clive Standley & Paul Walker & Adam Hurlstone & Kevin E. Fogarty & Nathan D. Lawson, 2010. "MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis," Nature, Nature, vol. 464(7292), pages 1196-1200, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7292:d:10.1038_nature08889
    DOI: 10.1038/nature08889
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