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Migrastatin analogues target fascin to block tumour metastasis

Author

Listed:
  • Lin Chen

    (Cornell University Weill Medical College, New York, New York 10065, USA)

  • Shengyu Yang

    (Cornell University Weill Medical College, New York, New York 10065, USA)

  • Jean Jakoncic

    (Brookhaven National Laboratory, National Synchrotron Light Source, Upton, New York 11973, USA)

  • J. Jillian Zhang

    (Cornell University Weill Medical College, New York, New York 10065, USA)

  • Xin-Yun Huang

    (Cornell University Weill Medical College, New York, New York 10065, USA)

Abstract

Fascin an anticancer target Analogues of the natural product migrastatin are potent inhibitors of tumour cell migration and metastasis. In this study, Lin Chen et al. elucidate the mechanism involved and show that these migrastatin analogues target and inhibit the activity of the actin bundling protein, fascin. These results suggest that actin cytoskeletal proteins, such as fascin, may present new molecular targets for cancer treatment.

Suggested Citation

  • Lin Chen & Shengyu Yang & Jean Jakoncic & J. Jillian Zhang & Xin-Yun Huang, 2010. "Migrastatin analogues target fascin to block tumour metastasis," Nature, Nature, vol. 464(7291), pages 1062-1066, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7291:d:10.1038_nature08978
    DOI: 10.1038/nature08978
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