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Fructose 1,6-bisphosphate aldolase/phosphatase may be an ancestral gluconeogenic enzyme

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  • Rafael F. Say

    (Mikrobiologie, Fakultät Biologie, Universität Freiburg, Schänzlestraße 1, D-79104 Freiburg, Germany)

  • Georg Fuchs

    (Mikrobiologie, Fakultät Biologie, Universität Freiburg, Schänzlestraße 1, D-79104 Freiburg, Germany)

Abstract

An ancestral gluconeogenic enzyme Many thermophilic bacteria and archaea use carbon dioxide or carbon monoxide as starting materials for the synthesis of organic material used for cellular molecules. A central enzyme in this pathway has now been identified as fructose 1,6-bisphosphate aldolase/phosphatase. This enzyme, which is missing in most other bacteria and in eukaryotes, has the characteristics required for a primordial autotrophic carbon metabolism. This adds supporting evidence for the hypothesis that life originated in a chemolithoautrophic thermophile and that glucogenesis evolved before glycolysis. This robust enzyme may also be biotechnologically valuable in producing engineered cells specialized for the production of carbohydrates.

Suggested Citation

  • Rafael F. Say & Georg Fuchs, 2010. "Fructose 1,6-bisphosphate aldolase/phosphatase may be an ancestral gluconeogenic enzyme," Nature, Nature, vol. 464(7291), pages 1077-1081, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7291:d:10.1038_nature08884
    DOI: 10.1038/nature08884
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