Author
Listed:
- Ling Zhang
(Department of Head and Neck Surgery,)
- Xiaoyang Ren
(Department of Head and Neck Surgery,)
- Eckhard Alt
(Department of Molecular Pathology,)
- Xiaowen Bai
(Department of Molecular Pathology,)
- Shaoyi Huang
(Department of Head and Neck Surgery,)
- Zhengming Xu
(Department of Head and Neck Surgery,)
- Patrick M. Lynch
(Hepatology and Nutrition, and)
- Mary P. Moyer
(INCELL Corporation, San Antonio, Texas 78249, USA)
- Xian-Feng Wen
(Department of Head and Neck Surgery,)
- Xiangwei Wu
(Department of Head and Neck Surgery,
The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)
Abstract
Induced apoptosis as anticancer therapy The membrane-bound tumour necrosis factor-related ligand TRAIL (also called TNFSF10 and Apo2L) is known to induce apoptosis or cell death in cancer cells but not in normal cells. With a view to developing a way of specifically targeting premalignant tumour cells for apoptosis, Zhang et al. report that in a mouse model a combination of TRAIL and all-trans-retinyl acetate (RAc) causes premalignant intestinal polyp or adenoma cells lacking the APC (adenomatous polyposis coli) gene to undergo apoptosis. Normal cells appear unaffected by the treatment, suggesting that the therapy, which also has the advantage of requiring short, intermittent treatment cycles rather than long-term exposure, could prove useful in preventing human colon cancer.
Suggested Citation
Ling Zhang & Xiaoyang Ren & Eckhard Alt & Xiaowen Bai & Shaoyi Huang & Zhengming Xu & Patrick M. Lynch & Mary P. Moyer & Xian-Feng Wen & Xiangwei Wu, 2010.
"Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis,"
Nature, Nature, vol. 464(7291), pages 1058-1061, April.
Handle:
RePEc:nat:nature:v:464:y:2010:i:7291:d:10.1038_nature08871
DOI: 10.1038/nature08871
Download full text from publisher
As the access to this document is restricted, you may want to search for a different version of it.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:464:y:2010:i:7291:d:10.1038_nature08871. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.