IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v464y2010i7290d10.1038_nature08945.html
   My bibliography  Save this article

Vascular endothelial growth factor B controls endothelial fatty acid uptake

Author

Listed:
  • Carolina E. Hagberg

    (Tissue Biology Group, Karolinska Institutet
    Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Karolinska Institutet, Box 240, SE-171 77 Stockholm, Sweden)

  • Annelie Falkevall

    (Tissue Biology Group, Karolinska Institutet
    Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Karolinska Institutet, Box 240, SE-171 77 Stockholm, Sweden)

  • Xun Wang

    (Tissue Biology Group, Karolinska Institutet
    Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Karolinska Institutet, Box 240, SE-171 77 Stockholm, Sweden)

  • Erik Larsson

    (Institute of Biomedicine, University of Gothenburg, Box 440, SE-405 30 Gothenburg, Sweden)

  • Jenni Huusko

    (A.I. Virtanen Institute, University of Kuopio, Box 1627, FIN-70211 Kuopio, Finland)

  • Ingrid Nilsson

    (Tissue Biology Group, Karolinska Institutet)

  • Laurens A. van Meeteren

    (Uppsala University, Rudbeck Laboratory)

  • Erik Samen

    (Karolinska Pharmacy, Karolinska University Hospital, Solna, SE-17176 Stockholm, Sweden
    Clinical Neurosciences, Karolinska Institutet)

  • Li Lu

    (Clinical Neurosciences, Karolinska Institutet)

  • Maarten Vanwildemeersch

    (Tissue Biology Group, Karolinska Institutet
    Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Karolinska Institutet, Box 240, SE-171 77 Stockholm, Sweden)

  • Joakim Klar

    (Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Karolinska Institutet, Box 240, SE-171 77 Stockholm, Sweden
    Uppsala University, Rudbeck Laboratory)

  • Guillem Genove

    (Laboratory of Vascular Biology, Karolinska Institutet)

  • Kristian Pietras

    (Tissue Biology Group, Karolinska Institutet
    Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Karolinska Institutet, Box 240, SE-171 77 Stockholm, Sweden)

  • Sharon Stone-Elander

    (Karolinska Pharmacy, Karolinska University Hospital, Solna, SE-17176 Stockholm, Sweden
    Clinical Neurosciences, Karolinska Institutet)

  • Lena Claesson-Welsh

    (Uppsala University, Rudbeck Laboratory)

  • Seppo Ylä-Herttuala

    (A.I. Virtanen Institute, University of Kuopio, Box 1627, FIN-70211 Kuopio, Finland)

  • Per Lindahl

    (Institute of Biomedicine, University of Gothenburg, Box 440, SE-405 30 Gothenburg, Sweden
    Wallenberg Laboratory for Cardiovascular Research, Bruna Stråket 16, Sahlgrenska University Hospital)

  • Ulf Eriksson

    (Tissue Biology Group, Karolinska Institutet
    Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Karolinska Institutet, Box 240, SE-171 77 Stockholm, Sweden)

Abstract

Lipids on the move VEGF-B, a vascular endothelial growth factor that is highly expressed in heart, skeletal muscle and brown adipose tissue, has been found to have an unexpected role in targeting lipids to peripheral tissues. VEGFs are familiar as major angiogenic regulators, but the detailed role of VEGF-B in blood vessel function had been unclear. Mice lacking VEGF-B accumulate lower amounts of lipids in muscle, heart and brown adipose tissue, and instead shunt them to white adipose tissue. The involvement of VEGF-B in redistributing lipids suggest possible novel strategies for modulating lipid accumulation in diabetes, obesity and cardiovascular diseases.

Suggested Citation

  • Carolina E. Hagberg & Annelie Falkevall & Xun Wang & Erik Larsson & Jenni Huusko & Ingrid Nilsson & Laurens A. van Meeteren & Erik Samen & Li Lu & Maarten Vanwildemeersch & Joakim Klar & Guillem Genov, 2010. "Vascular endothelial growth factor B controls endothelial fatty acid uptake," Nature, Nature, vol. 464(7290), pages 917-921, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7290:d:10.1038_nature08945
    DOI: 10.1038/nature08945
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08945
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08945?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to

    for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:464:y:2010:i:7290:d:10.1038_nature08945. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.