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Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication

Author

Listed:
  • Bridgett M. vonHoldt

    (621 Charles E. Young Drive South, University of California, Los Angeles, California 90095, USA)

  • John P. Pollinger

    (621 Charles E. Young Drive South, University of California, Los Angeles, California 90095, USA)

  • Kirk E. Lohmueller

    (Cornell University, Ithaca, New York 14853-2601, USA)

  • Eunjung Han

    (University of California, Los Angeles, California 14853, USA)

  • Heidi G. Parker

    (Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Pascale Quignon

    (Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Jeremiah D. Degenhardt

    (Cornell University, Ithaca, New York 14853-2601, USA)

  • Adam R. Boyko

    (Cornell University, Ithaca, New York 14853-2601, USA)

  • Dent A. Earl

    (University of California, Santa Cruz, California 95064, USA)

  • Adam Auton

    (Cornell University, Ithaca, New York 14853-2601, USA)

  • Andy Reynolds

    (Cornell University, Ithaca, New York 14853-2601, USA)

  • Kasia Bryc

    (Cornell University, Ithaca, New York 14853-2601, USA)

  • Abra Brisbin

    (Cornell University, Ithaca, New York 14853-2601, USA)

  • James C. Knowles

    (621 Charles E. Young Drive South, University of California, Los Angeles, California 90095, USA)

  • Dana S. Mosher

    (Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Tyrone C. Spady

    (Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Abdel Elkahloun

    (Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Eli Geffen

    (Tel Aviv University)

  • Malgorzata Pilot

    (Museum and Institute of Zoology, Polish Academy of Sciences, Wilcza 64, 00-679 Warszawa, Poland)

  • Wlodzimierz Jedrzejewski

    (Mammal Research Institute, Polish Academy of Sciences)

  • Claudia Greco

    (Instituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA))

  • Ettore Randi

    (Instituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA))

  • Danika Bannasch

    (School of Veterinary Medicine, University of California, Davis, California 95616, USA)

  • Alan Wilton

    (School of Biotechnology and Biomolecular Sciences and Clive and Vera Ramaciotti Center for Gene Function Analysis, University of New South Wales)

  • Jeremy Shearman

    (School of Biotechnology and Biomolecular Sciences and Clive and Vera Ramaciotti Center for Gene Function Analysis, University of New South Wales)

  • Marco Musiani

    (Faculty of Environmental Design, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada)

  • Michelle Cargill

    (Affymetrix Corporation, 3420 Central Expressway, Santa Clara, California 95051, USA)

  • Paul G. Jones

    (The WALTHAM Centre for Pet Nutrition, Waltham on the Worlds, Leicestershire LE14 4RT, UK)

  • Zuwei Qian

    (Affymetrix Asia Pacific, Scientific Affairs and Collaborations, 1233 Lujiazui Ring Road, AZIA Center, Suite 1508, Shanghai 200120, China)

  • Wei Huang

    (Affymetrix Asia Pacific, Scientific Affairs and Collaborations, 1233 Lujiazui Ring Road, AZIA Center, Suite 1508, Shanghai 200120, China)

  • Zhao-Li Ding

    (Laboratory for Conservation and Utilization of Bio-resources, Yunnan University)

  • Ya-ping Zhang

    (State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences)

  • Carlos D. Bustamante

    (Cornell University, Ithaca, New York 14853-2601, USA)

  • Elaine A. Ostrander

    (Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • John Novembre

    (621 Charles E. Young Drive South, University of California, Los Angeles, California 90095, USA
    621 Charles E. Young Drive South, University of California, Los Angeles, California 90095, USA)

  • Robert K. Wayne

    (621 Charles E. Young Drive South, University of California, Los Angeles, California 90095, USA)

Abstract

Dog breeds, old and new The development of the domestic dog is a fascinating example of a dramatic radiation in form and function that has occurred rapidly in association with the expansion of human civilization. An extensive genome-wide survey of over 48,000 single nucleotide polymorphisms in dogs and their wild progenitor, the grey wolf, reveals striking patterns of genetic subdivision. Two clearly divergent clusters emerge, one of ancient breeds and the other of modern breeds created in the nineteenth century. An analysis of haplotype sharing suggests that the dog has a dominant Middle Eastern or European origin, consistent with recent archaeological finds, rather than one in East Asia as suggested previously by mitochondrial DNA data.

Suggested Citation

  • Bridgett M. vonHoldt & John P. Pollinger & Kirk E. Lohmueller & Eunjung Han & Heidi G. Parker & Pascale Quignon & Jeremiah D. Degenhardt & Adam R. Boyko & Dent A. Earl & Adam Auton & Andy Reynolds & K, 2010. "Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication," Nature, Nature, vol. 464(7290), pages 898-902, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7290:d:10.1038_nature08837
    DOI: 10.1038/nature08837
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