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Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4

Author

Listed:
  • Eric Metzger

    (Urologische Klinik/Frauenklinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66,)

  • Axel Imhof

    (Adolf-Butenandt Institute and Munich Center of Integrated Protein Science (CIPS), Ludwig Maximilians University of Munich, Schillerstrasse 44, 80336 Munich, Germany)

  • Dharmeshkumar Patel

    (Urologische Klinik/Frauenklinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66,)

  • Philip Kahl

    (Institut für Pathologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany)

  • Katrin Hoffmeyer

    (Urologische Klinik/Frauenklinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66,)

  • Nicolaus Friedrichs

    (Urologische Klinik/Frauenklinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66,)

  • Judith M. Müller

    (Urologische Klinik/Frauenklinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66,)

  • Holger Greschik

    (Urologische Klinik/Frauenklinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66,)

  • Jutta Kirfel

    (Institut für Pathologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany)

  • Sujuan Ji

    (Urologische Klinik/Frauenklinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66,)

  • Natalia Kunowska

    (Urologische Klinik/Frauenklinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66,)

  • Christian Beisenherz-Huss

    (ProQinase, Breisacherstrasse 117, 79106 Freiburg, Germany)

  • Thomas Günther

    (Urologische Klinik/Frauenklinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66,)

  • Reinhard Buettner

    (Institut für Pathologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany)

  • Roland Schüle

    (Urologische Klinik/Frauenklinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66,)

Abstract

Histone demethylation mechanisms The N-terminal tails of histones are subject to a variety of post-translational modifications; addition or removal of these marks by specific enzymes facilitates gene activation or silencing. Here, a mechanism is defined that modulates the activity of the dual specificity histone demethylase LSD1 during androgen-dependent transcription. Androgen-dependent signalling through protein kinase C beta I leads to phosphorylation of a histone residue that prevents demethylation of an adjacent residue by LSD1. This mechanism may potentially be important in prostate cancer.

Suggested Citation

  • Eric Metzger & Axel Imhof & Dharmeshkumar Patel & Philip Kahl & Katrin Hoffmeyer & Nicolaus Friedrichs & Judith M. Müller & Holger Greschik & Jutta Kirfel & Sujuan Ji & Natalia Kunowska & Christian Be, 2010. "Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4," Nature, Nature, vol. 464(7289), pages 792-796, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7289:d:10.1038_nature08839
    DOI: 10.1038/nature08839
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