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Compensatory evolution in mitochondrial tRNAs navigates valleys of low fitness

Author

Listed:
  • Margarita V. Meer

    (Bioinformatics and Genomics Programme, Centre for Genomic Regulation, C/Dr Aiguader 88, Barcelona Biomedical Research Park Building, 08003 Barcelona, Spain)

  • Alexey S. Kondrashov

    (Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA)

  • Yael Artzy-Randrup

    (Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    University of Michigan, Ann Arbor, Michigan 49109, USA)

  • Fyodor A. Kondrashov

    (Bioinformatics and Genomics Programme, Centre for Genomic Regulation, C/Dr Aiguader 88, Barcelona Biomedical Research Park Building, 08003 Barcelona, Spain)

Abstract

The landscape of evolution Evolution from one fitness peak to another fitness peak must either involve transitioning through intermediates of low fitness or skirting round the fitness valley through compensatory mutations elsewhere. Meer et al. use the base pairs in mitochondrial tRNA stems as a model to show that deep fitness valleys can be traversed. They show that transitions between AU and GC pairs have occurred during mammalian evolution without help from genetic drift or mutations elsewhere.

Suggested Citation

  • Margarita V. Meer & Alexey S. Kondrashov & Yael Artzy-Randrup & Fyodor A. Kondrashov, 2010. "Compensatory evolution in mitochondrial tRNAs navigates valleys of low fitness," Nature, Nature, vol. 464(7286), pages 279-282, March.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7286:d:10.1038_nature08691
    DOI: 10.1038/nature08691
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