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Reprogramming towards pluripotency requires AID-dependent DNA demethylation

Author

Listed:
  • Nidhi Bhutani

    (Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5175, USA)

  • Jennifer J. Brady

    (Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5175, USA)

  • Mara Damian

    (Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5175, USA
    Stanford University, Stanford, California 94305-5175, USA)

  • Alessandra Sacco

    (Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5175, USA)

  • Stéphane Y. Corbel

    (Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5175, USA)

  • Helen M. Blau

    (Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5175, USA)

Abstract

Reprogramming of somatic cell nuclei to yield induced pluripotent stem (iPS) cells makes possible derivation of patient-specific stem cells for regenerative medicine. However, iPS cell generation is asynchronous and slow (2–3 weeks), the frequency is low (

Suggested Citation

  • Nidhi Bhutani & Jennifer J. Brady & Mara Damian & Alessandra Sacco & Stéphane Y. Corbel & Helen M. Blau, 2010. "Reprogramming towards pluripotency requires AID-dependent DNA demethylation," Nature, Nature, vol. 463(7284), pages 1042-1047, February.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7284:d:10.1038_nature08752
    DOI: 10.1038/nature08752
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