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Ancient animal microRNAs and the evolution of tissue identity

Author

Listed:
  • Foteini Christodoulou

    (Developmental Biology Unit,)

  • Florian Raible

    (Developmental Biology Unit,
    Computational Biology Unit, European Molecular Biology Laboratory, D-69117 Heidelberg, Germany
    Present addresses: Max F. Perutz Laboratories, Campus Vienna Biocenter, Dr. Bohr-Gasse 9/4, A-1030 Vienna, Austria (F.R.); J. W. Goethe - Universität Frankfurt Biologie-Campus, Siesmayerstrasse 70-72, D-60323 Frankfurt, Germany (S.K.).)

  • Raju Tomer

    (Developmental Biology Unit,)

  • Oleg Simakov

    (Developmental Biology Unit,)

  • Kalliopi Trachana

    (Computational Biology Unit, European Molecular Biology Laboratory, D-69117 Heidelberg, Germany)

  • Sebastian Klaus

    (Developmental Biology Unit,
    Present addresses: Max F. Perutz Laboratories, Campus Vienna Biocenter, Dr. Bohr-Gasse 9/4, A-1030 Vienna, Austria (F.R.); J. W. Goethe - Universität Frankfurt Biologie-Campus, Siesmayerstrasse 70-72, D-60323 Frankfurt, Germany (S.K.).)

  • Heidi Snyman

    (Developmental Biology Unit,)

  • Gregory J. Hannon

    (Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Peer Bork

    (Computational Biology Unit, European Molecular Biology Laboratory, D-69117 Heidelberg, Germany)

  • Detlev Arendt

    (Developmental Biology Unit,)

Abstract

An oral tradition for microRNA Recent work suggests that microRNAs, the ubiquitous, small, non-coding genetic elements with important regulatory roles, were important in the evolution of complexity in multicellular animals. What was the role of these microRNAs when they first evolved? A deep sequencing study of the marine ragworm Platynereis dumerilii, and comparison with other bilaterian animals, suggests that the most ancient known microRNA, miR-100, was initially active in neurosecretory cells around the mouth. Other highly conserved varieties were first present in specific tissues and organ systems, such as ciliated cells and parts of the nervous system, musculature and gut. This work suggests that the last common ancestor of bilaterian animals already had all these structures.

Suggested Citation

  • Foteini Christodoulou & Florian Raible & Raju Tomer & Oleg Simakov & Kalliopi Trachana & Sebastian Klaus & Heidi Snyman & Gregory J. Hannon & Peer Bork & Detlev Arendt, 2010. "Ancient animal microRNAs and the evolution of tissue identity," Nature, Nature, vol. 463(7284), pages 1084-1088, February.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7284:d:10.1038_nature08744
    DOI: 10.1038/nature08744
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