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Tbx3 improves the germ-line competency of induced pluripotent stem cells

Author

Listed:
  • Jianyong Han

    (Stem Cell and Developmental Biology,
    State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University)

  • Ping Yuan

    (Stem Cell and Developmental Biology,)

  • Henry Yang

    (Singapore Immunology Network, 138648, Singapore)

  • Jinqiu Zhang

    (Stem Cell and Developmental Biology,)

  • Boon Seng Soh

    (Stem Cell and Developmental Biology,)

  • Pin Li

    (Stem Cell and Developmental Biology,)

  • Siew Lan Lim

    (Stem Cell and Developmental Biology,)

  • Suying Cao

    (Stem Cell and Developmental Biology,)

  • Junliang Tay

    (Stem Cell and Developmental Biology,)

  • Yuriy L. Orlov

    (Systems Biology, Genome Institute of Singapore, 138672, Singapore)

  • Thomas Lufkin

    (Stem Cell and Developmental Biology,)

  • Huck-Hui Ng

    (Stem Cell and Developmental Biology,
    National University of Singapore, 117543, Singapore)

  • Wai-Leong Tam

    (Stem Cell and Developmental Biology,
    Present address: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.)

  • Bing Lim

    (Stem Cell and Developmental Biology,
    Center for Life Sciences, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Tbx3 boosts iPS quality While much attention has been given to the study of different genetic and chemical methods for the generation of iPS (induced pluripotent stem) cell lines, relatively little is known about the variability in overall quality of iPS cells. This paper identifies a transcription factor, Tbx3, that significantly improves the quality of iPS cells. Tbx3 also accelerates the reprogramming process of mouse embryonic fibroblasts into iPS cells and significantly improves the germ-line transmission of iPS-derived germ cells in chimaeric animals.

Suggested Citation

  • Jianyong Han & Ping Yuan & Henry Yang & Jinqiu Zhang & Boon Seng Soh & Pin Li & Siew Lan Lim & Suying Cao & Junliang Tay & Yuriy L. Orlov & Thomas Lufkin & Huck-Hui Ng & Wai-Leong Tam & Bing Lim, 2010. "Tbx3 improves the germ-line competency of induced pluripotent stem cells," Nature, Nature, vol. 463(7284), pages 1096-1100, February.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7284:d:10.1038_nature08735
    DOI: 10.1038/nature08735
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