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Rere controls retinoic acid signalling and somite bilateral symmetry

Author

Listed:
  • Gonçalo C. Vilhais-Neto

    (Stowers Institute for Medical Research,
    Present address: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS (UMR 7104), Inserm U964, Université de Strasbourg, Illkirch F-67400, France.)

  • Mitsuji Maruhashi

    (Stowers Institute for Medical Research,
    Howard Hughes Medical Institute, Kansas City, Missouri 64110, USA
    Present address: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS (UMR 7104), Inserm U964, Université de Strasbourg, Illkirch F-67400, France.)

  • Karen T. Smith

    (Stowers Institute for Medical Research,)

  • Mireille Vasseur-Cognet

    (Metabolism, and Cancer, Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Inserm U567, Paris, France)

  • Andrew S. Peterson

    (Genentech, South San Francisco, California 94080, USA)

  • Jerry L. Workman

    (Stowers Institute for Medical Research,)

  • Olivier Pourquié

    (Stowers Institute for Medical Research,
    Howard Hughes Medical Institute, Kansas City, Missouri 64110, USA
    University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Present address: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS (UMR 7104), Inserm U964, Université de Strasbourg, Illkirch F-67400, France.)

Abstract

Bilateral symmetry The skeletal muscles and vertebrae of the vertebrate body plan show striking bilateral symmetry although this is disrupted in conditions like scoliosis, in which the spine becomes curved. This paper provides insight as to how this symmetry is maintained. A mutation in the Rere (atrophin2) gene is shown to lead to the formation of asymmetrical somites. In addition, Rere controls retinoic acid signalling, which is required to maintain somite symmetry by interacting with Fgf8 in the left–right signalling pathway. Rere forms a complex with Nr2f2, p300 and the retinoic acid receptor (RAR), and this complex is recruited to the retinoic acid regulatory element (RARE) of retinoic acid targets.

Suggested Citation

  • Gonçalo C. Vilhais-Neto & Mitsuji Maruhashi & Karen T. Smith & Mireille Vasseur-Cognet & Andrew S. Peterson & Jerry L. Workman & Olivier Pourquié, 2010. "Rere controls retinoic acid signalling and somite bilateral symmetry," Nature, Nature, vol. 463(7283), pages 953-957, February.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7283:d:10.1038_nature08763
    DOI: 10.1038/nature08763
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