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Neural bases for addictive properties of benzodiazepines

Author

Listed:
  • Kelly R. Tan

    (Medical Faculty, University of Geneva)

  • Matthew Brown

    (Medical Faculty, University of Geneva)

  • Gwenaël Labouèbe

    (Medical Faculty, University of Geneva)

  • Cédric Yvon

    (Medical Faculty, University of Geneva)

  • Cyril Creton

    (Medical Faculty, University of Geneva)

  • Jean-Marc Fritschy

    (Institute of Pharmacology and Toxicology, University of Zurich)

  • Uwe Rudolph

    (Laboratory of Genetic Neuropharmacology, Harvard Medical School, Belmont, Massachusetts 02478, USA)

  • Christian Lüscher

    (Medical Faculty, University of Geneva
    Clinic of Neurology, Geneva University Hospital
    Geneva Neuroscience Center)

Abstract

Benzodiazepines are widely used in clinics and for recreational purposes, but will lead to addiction in vulnerable individuals. Addictive drugs increase the levels of dopamine and also trigger long-lasting synaptic adaptations in the mesolimbic reward system that ultimately may induce the pathological behaviour. The neural basis for the addictive nature of benzodiazepines, however, remains elusive. Here we show that benzodiazepines increase firing of dopamine neurons of the ventral tegmental area through the positive modulation of GABAA (γ-aminobutyric acid type A) receptors in nearby interneurons. Such disinhibition, which relies on α1-containing GABAA receptors expressed in these cells, triggers drug-evoked synaptic plasticity in excitatory afferents onto dopamine neurons and underlies drug reinforcement. Taken together, our data provide evidence that benzodiazepines share defining pharmacological features of addictive drugs through cell-type-specific expression of α1-containing GABAA receptors in the ventral tegmental area. The data also indicate that subunit-selective benzodiazepines sparing α1 may be devoid of addiction liability.

Suggested Citation

  • Kelly R. Tan & Matthew Brown & Gwenaël Labouèbe & Cédric Yvon & Cyril Creton & Jean-Marc Fritschy & Uwe Rudolph & Christian Lüscher, 2010. "Neural bases for addictive properties of benzodiazepines," Nature, Nature, vol. 463(7282), pages 769-774, February.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7282:d:10.1038_nature08758
    DOI: 10.1038/nature08758
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