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Towards building a chromosome segregation machine

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  • Kerry Bloom

    (622 Fordham Hall, CB3280, University of North Carolina at Chapel Hill)

  • Ajit Joglekar

    (622 Fordham Hall, CB3280, University of North Carolina at Chapel Hill)

Abstract

All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 × 109 base pairs) of DNA when each cell divides. This task is carried out up to a trillion times during the development of a human from a single fertilized cell. The strategy by which DNA is replicated is now well understood. But when it comes to packaging and segregating a genome, the mechanisms are only beginning to be understood and are often as variable as the organisms in which they are studied.

Suggested Citation

  • Kerry Bloom & Ajit Joglekar, 2010. "Towards building a chromosome segregation machine," Nature, Nature, vol. 463(7280), pages 446-456, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7280:d:10.1038_nature08912
    DOI: 10.1038/nature08912
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