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Cell mechanics and the cytoskeleton

Author

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  • Daniel A. Fletcher

    (Bioengineering and Biophysics, University of California
    Physical Biosciences, Lawrence Berkeley National Laboratory)

  • R. Dyche Mullins

    (Cellular and Molecular Pharmacology, University of California)

Abstract

The ability of a eukaryotic cell to resist deformation, to transport intracellular cargo and to change shape during movement depends on the cytoskeleton, an interconnected network of filamentous polymers and regulatory proteins. Recent work has demonstrated that both internal and external physical forces can act through the cytoskeleton to affect local mechanical properties and cellular behaviour. Attention is now focused on how cytoskeletal networks generate, transmit and respond to mechanical signals over both short and long timescales. An important insight emerging from this work is that long-lived cytoskeletal structures may act as epigenetic determinants of cell shape, function and fate.

Suggested Citation

  • Daniel A. Fletcher & R. Dyche Mullins, 2010. "Cell mechanics and the cytoskeleton," Nature, Nature, vol. 463(7280), pages 485-492, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7280:d:10.1038_nature08908
    DOI: 10.1038/nature08908
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    Cited by:

    1. Mariafrancesca Cascione & Valeria De Matteis & Rosaria Rinaldi, 2019. "Cytomechanical Alterations Induced by Inorganic NPs," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 14(4), pages 1-2, February.
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    3. Nishkantha Arulkumaran & Mervyn Singer & Stefan Howorka & Jonathan R. Burns, 2023. "Creating complex protocells and prototissues using simple DNA building blocks," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Matt D. G. Hughes & Sophie Cussons & Benjamin S. Hanson & Kalila R. Cook & Tímea Feller & Najet Mahmoudi & Daniel L. Baker & Robert Ariëns & David A. Head & David J. Brockwell & Lorna Dougan, 2023. "Building block aspect ratio controls assembly, architecture, and mechanics of synthetic and natural protein networks," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    5. Chao Jiang & Hong-Yu Luo & Xinpeng Xu & Shuo-Xing Dou & Wei Li & Dongshi Guan & Fangfu Ye & Xiaosong Chen & Ming Guo & Peng-Ye Wang & Hui Li, 2023. "Switch of cell migration modes orchestrated by changes of three-dimensional lamellipodium structure and intracellular diffusion," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    6. Chrystian Junqueira Alves & Rafael Dariolli & Jonathan Haydak & Sangjo Kang & Theodore Hannah & Robert J. Wiener & Stefanie DeFronzo & Rut Tejero & Gabriele L. Gusella & Aarthi Ramakrishnan & Rodrigo , 2021. "Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion," Nature Communications, Nature, vol. 12(1), pages 1-23, December.
    7. Jiu-Tao Hang & Yu Kang & Guang-Kui Xu & Huajian Gao, 2021. "A hierarchical cellular structural model to unravel the universal power-law rheological behavior of living cells," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
    8. Yuji Shimizu & Takanori Kihara & Seyed Mohammad Ali Haghparast & Shunsuke Yuba & Jun Miyake, 2012. "Simple Display System of Mechanical Properties of Cells and Their Dispersion," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-8, March.
    9. Reena Kumari & Katharina Ven & Megan Chastney & Shrikant B. Kokate & Johan Peränen & Jesse Aaron & Konstantin Kogan & Leonardo Almeida-Souza & Elena Kremneva & Renaud Poincloux & Teng-Leong Chew & Pet, 2024. "Focal adhesions contain three specialized actin nanoscale layers," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    10. Gaurav Luthria & Ran Li & Stephanie Wang & Mark Prytyskach & Rainer H. Kohler & Douglas A. Lauffenburger & Timothy J. Mitchison & Ralph Weissleder & Miles A. Miller, 2020. "In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    11. Jindal, Akriti & Gupta, Arvind Kumar, 2021. "Effect of local dissociation on symmetry breaking in exclusion model constituted by bridge lane and input-output TASEPs," Chaos, Solitons & Fractals, Elsevier, vol. 152(C).
    12. Suchet Nanda & Abram Calderon & Arya Sachan & Thanh-Thuy Duong & Johannes Koch & Xiaoyi Xin & Djamschid Solouk-Stahlberg & Yao-Wen Wu & Perihan Nalbant & Leif Dehmelt, 2023. "Rho GTPase activity crosstalk mediated by Arhgef11 and Arhgef12 coordinates cell protrusion-retraction cycles," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    13. Keren Lasker & Steven Boeynaems & Vinson Lam & Daniel Scholl & Emma Stainton & Adam Briner & Maarten Jacquemyn & Dirk Daelemans & Ashok Deniz & Elizabeth Villa & Alex S. Holehouse & Aaron D. Gitler & , 2022. "The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    14. Alves Ribeiro, Marcus V. & Jurjiu, Aurel & Galiceanu, Mircea, 2022. "Dynamics of semiflexible generalized scale-free polymer networks," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 606(C).
    15. Antoine Vian & Marie Pochitaloff & Shuo-Ting Yen & Sangwoo Kim & Jennifer Pollock & Yucen Liu & Ellen M. Sletten & Otger Campàs, 2023. "In situ quantification of osmotic pressure within living embryonic tissues," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    16. Muqing Cao & Xiaoxiao Zou & Chaoyi Li & Zaisheng Lin & Ni Wang & Zhongju Zou & Youqiong Ye & Joachim Seemann & Beth Levine & Zaiming Tang & Qing Zhong, 2023. "An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    17. Venkat R. Chirasani & Mohammad Ashhar I. Khan & Juilee N. Malavade & Nikolay V. Dokholyan & Brenton D. Hoffman & Sharon L. Campbell, 2023. "Molecular basis and cellular functions of vinculin-actin directional catch bonding," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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