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Interaction between RasV12 and scribbled clones induces tumour growth and invasion

Author

Listed:
  • Ming Wu

    (Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06519, USA)

  • José Carlos Pastor-Pareja

    (Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06519, USA)

  • Tian Xu

    (Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06519, USA
    Fudan-Yale Biomedical Research Center, Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, 220 Han Dan Road, Shanghai 20043, China)

Abstract

Cell–cell communication in tumours In a genetically well-defined model system in Drosophila, Tian Xu and colleagues show that cell clones carrying distinct oncogenic mutations can cooperate to produce invasive tumours. This cooperation involves JNK and JAK/STAT signalling pathways. Similar cooperative mechanism might be at play in the communication between genetically heterogeneous human cancer cells or between tumour cells and their microenvironment.

Suggested Citation

  • Ming Wu & José Carlos Pastor-Pareja & Tian Xu, 2010. "Interaction between RasV12 and scribbled clones induces tumour growth and invasion," Nature, Nature, vol. 463(7280), pages 545-548, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7280:d:10.1038_nature08702
    DOI: 10.1038/nature08702
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    Cited by:

    1. Marilyn Goudreault & Valérie Gagné & Chang Hwa Jo & Swati Singh & Ryan C. Killoran & Anne-Claude Gingras & Matthew J. Smith, 2022. "Afadin couples RAS GTPases to the polarity rheostat Scribble," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Tilak Abeysinghe & Jiaying Gu, 2010. "The Cultural Revolution, Stress and Cancer," Microeconomics Working Papers 23118, East Asian Bureau of Economic Research.

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