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Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen

Author

Listed:
  • Frédéric Bienvenu

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Siwanon Jirawatnotai

    (Dana-Farber Cancer Institute, Harvard Medical School
    Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Prathom, 73170 Thailand)

  • Joshua E. Elias

    (Harvard Medical School
    Present address: Stanford University School of Medicine, Stanford, California 94305, USA.)

  • Clifford A. Meyer

    (Dana-Farber Cancer Institute and Harvard School of Public Health)

  • Karolina Mizeracka

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Alexander Marson

    (Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA)

  • Garrett M. Frampton

    (Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA)

  • Megan F. Cole

    (Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA)

  • Duncan T. Odom

    (Cancer Research UK-Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK)

  • Junko Odajima

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Yan Geng

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Agnieszka Zagozdzon

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Marie Jecrois

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Richard A. Young

    (Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA)

  • X. Shirley Liu

    (Dana-Farber Cancer Institute and Harvard School of Public Health)

  • Constance L. Cepko

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Steven P. Gygi

    (Harvard Medical School)

  • Piotr Sicinski

    (Dana-Farber Cancer Institute, Harvard Medical School)

Abstract

Cyclin D1 in development A proteomics approach to screening for cyclin D1-binding proteins in various mouse organs reveals proteins involved in transcription regulation. Cyclin D1 is found to be associated with the promoter regions of many genes, and a role for cyclin D1 in regulating Notch1 gene expression in the developing mouse retina is dissected in detail. These findings suggest that cyclin D1 has a transcription regulatory function during development, in addition to its well-established cell-cycle roles.

Suggested Citation

  • Frédéric Bienvenu & Siwanon Jirawatnotai & Joshua E. Elias & Clifford A. Meyer & Karolina Mizeracka & Alexander Marson & Garrett M. Frampton & Megan F. Cole & Duncan T. Odom & Junko Odajima & Yan Geng, 2010. "Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen," Nature, Nature, vol. 463(7279), pages 374-378, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7279:d:10.1038_nature08684
    DOI: 10.1038/nature08684
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