IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v463y2010i7279d10.1038_nature08672.html
   My bibliography  Save this article

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

Author

Listed:
  • Gillian L. Dalgliesh

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Kyle Furge

    (Laboratory of Computational Biology,)

  • Chris Greenman

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Lina Chen

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Graham Bignell

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Adam Butler

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Helen Davies

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Sarah Edkins

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Claire Hardy

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Calli Latimer

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Jon Teague

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Jenny Andrews

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Syd Barthorpe

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Dave Beare

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Gemma Buck

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Peter J. Campbell

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Simon Forbes

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Mingming Jia

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • David Jones

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Henry Knott

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Chai Yin Kok

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • King Wai Lau

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Catherine Leroy

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Meng-Lay Lin

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • David J. McBride

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Mark Maddison

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Simon Maguire

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Kirsten McLay

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Andrew Menzies

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Tatiana Mironenko

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Lee Mulderrig

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Laura Mudie

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Sarah O’Meara

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Erin Pleasance

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Arjunan Rajasingham

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Rebecca Shepherd

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Raffaella Smith

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Lucy Stebbings

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Philip Stephens

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Gurpreet Tang

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Patrick S. Tarpey

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Kelly Turrell

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Karl J. Dykema

    (Laboratory of Computational Biology,)

  • Sok Kean Khoo

    (Laboratory of Cancer Genertics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA)

  • David Petillo

    (Laboratory of Cancer Genertics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA)

  • Bill Wondergem

    (Laboratory of Computational Biology,)

  • John Anema

    (Spectrum Health Hospital, Grand Rapids, Michigan 49503, USA)

  • Richard J. Kahnoski

    (Spectrum Health Hospital, Grand Rapids, Michigan 49503, USA)

  • Bin Tean Teh

    (Laboratory of Cancer Genertics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    NCCS-VARI Translational Cancer Research Laboratory, National Cancer Centre)

  • Michael R. Stratton

    (Cancer Genome Project, Wellcome Trust Sanger Institute
    Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK)

  • P. Andrew Futreal

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

Abstract

Chromatin modification in renal carcinoma A large survey for somatic mutations in clear cell renal cell carcinomas, the most common form of adult kidney cancer, shows that in addition to the known inactivating mutations in the VHL gene, recurrent mutations occur in the NF2 gene, which encodes a tumour suppressor protein and in genes encoding the chromatin modifying enzymes SETD2, JARID1C and UTX.

Suggested Citation

  • Gillian L. Dalgliesh & Kyle Furge & Chris Greenman & Lina Chen & Graham Bignell & Adam Butler & Helen Davies & Sarah Edkins & Claire Hardy & Calli Latimer & Jon Teague & Jenny Andrews & Syd Barthorpe , 2010. "Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes," Nature, Nature, vol. 463(7279), pages 360-363, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7279:d:10.1038_nature08672
    DOI: 10.1038/nature08672
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08672
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08672?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. repec:plo:pone00:0140257 is not listed on IDEAS

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:463:y:2010:i:7279:d:10.1038_nature08672. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.