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Essentiality of FASII pathway for Staphylococcus aureus

Author

Listed:
  • Wendy Balemans

    (Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium. akoul@its.jnj.com)

  • Nacer Lounis

    (Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium. akoul@its.jnj.com)

  • Ron Gilissen

    (Pharmaceutical Research and Development, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium)

  • Jerome Guillemont

    (Centre de Recherche Janssen-Cilag, Johnson & Johnson, Campus de Maigremont BP615, F-27106 Val de Reuil cedex, France)

  • Kenny Simmen

    (Tibotec BVBA, Johnson & Johnson, Gen. De Wittelaan L 11B 3, B-2800 Mechelen, Belgium)

  • Koen Andries

    (Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium. akoul@its.jnj.com)

  • Anil Koul

    (Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium. akoul@its.jnj.com)

Abstract

Arising from: S. Brinster et al. Nature 458, 83–86 (2009)10.1038/nature07772 ; Brinster et al. reply Recently, Brinster et al.1 suggested that type II fatty-acid biosynthesis (FASII) is not a suitable antibacterial target for Gram-positive pathogens because they use fatty acids directly from host serum rather than de novo synthesis. Their findings, if confirmed, are relevant for further scientific and financial investments in the development of new drugs targeting FASII. We present here in vitro and in vivo data demonstrating that their observations do not hold for Staphylococcus aureus, a major Gram-positive pathogen causing several human infections. The observed differences among Gram-positive pathogens in FASII reflects heterogeneity either in fatty-acid synthesis or in the capacity for fatty-acid uptake from the environment.

Suggested Citation

  • Wendy Balemans & Nacer Lounis & Ron Gilissen & Jerome Guillemont & Kenny Simmen & Koen Andries & Anil Koul, 2010. "Essentiality of FASII pathway for Staphylococcus aureus," Nature, Nature, vol. 463(7279), pages 3-3, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7279:d:10.1038_nature08667
    DOI: 10.1038/nature08667
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