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Endogenous non-retroviral RNA virus elements in mammalian genomes

Author

Listed:
  • Masayuki Horie

    (Research Institute for Microbial Diseases (BIKEN), Osaka University)

  • Tomoyuki Honda

    (Research Institute for Microbial Diseases (BIKEN), Osaka University
    Japan Society for the Promotion of Science (JSPS), Chiyoda-ku, Tokyo 102-8472, Japan)

  • Yoshiyuki Suzuki

    (Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan)

  • Yuki Kobayashi

    (Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan)

  • Takuji Daito

    (Research Institute for Microbial Diseases (BIKEN), Osaka University)

  • Tatsuo Oshida

    (Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan)

  • Kazuyoshi Ikuta

    (Research Institute for Microbial Diseases (BIKEN), Osaka University)

  • Patric Jern

    (Tufts University School of Medicine, Boston, Massachusetts 02111, USA)

  • Takashi Gojobori

    (Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan)

  • John M. Coffin

    (Tufts University School of Medicine, Boston, Massachusetts 02111, USA)

  • Keizo Tomonaga

    (Research Institute for Microbial Diseases (BIKEN), Osaka University
    PRESTO, Japan Science and Technology Agency (JST), Chiyoda-ku, Tokyo 102-0075, Japan)

Abstract

Viral 'fossils' in the genome DNA derived from endogenous retroviruses is a common ancestral feature in mammalian genomes. Until now retroviruses have been the only group of viruses known to have left a fossil record of this type, but now elements derived from Borna-like N (EBLN) sequences have been found in the genomes of humans, non-human primates, rodents and a species of ground squirrel. Bornaviruses are non-segmented, negative-strand RNA viruses that replicate in the nucleus of infected cells. In primates, the elements are very old, formed more than 40 million years ago, while squirrel EBLN sequences are a more recent introduction. The conservation of open reading frames of primate EBLNs, as well as their expression as mRNA, implies that they may function as a source of genetic novelty in their host.

Suggested Citation

  • Masayuki Horie & Tomoyuki Honda & Yoshiyuki Suzuki & Yuki Kobayashi & Takuji Daito & Tatsuo Oshida & Kazuyoshi Ikuta & Patric Jern & Takashi Gojobori & John M. Coffin & Keizo Tomonaga, 2010. "Endogenous non-retroviral RNA virus elements in mammalian genomes," Nature, Nature, vol. 463(7277), pages 84-87, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7277:d:10.1038_nature08695
    DOI: 10.1038/nature08695
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    Cited by:

    1. Hengrui Hu & Just M. Vlak & Zhihong Hu & Manli Wang, 2025. "Discovery of novel non-retroviral endogenous viral elements reveals their long-term integration history in spiders," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
    2. Hai-Jian Huang & Yi-Yuan Li & Zhuang-Xin Ye & Li-Li Li & Qing-Ling Hu & Yu-Juan He & Yu-Hua Qi & Yan Zhang & Ting Li & Gang Lu & Qian-Zhuo Mao & Ji-Chong Zhuo & Jia-Bao Lu & Zhong-Tian Xu & Zong-Tao S, 2023. "Co-option of a non-retroviral endogenous viral element in planthoppers," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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