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Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

Author

Listed:
  • R. Eric Davis

    (Metabolism Branch,)

  • Vu N. Ngo

    (Metabolism Branch,)

  • Georg Lenz

    (Metabolism Branch,)

  • Pavel Tolar

    (Laboratory of Immunogenetics, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA)

  • Ryan M. Young

    (Metabolism Branch,)

  • Paul B. Romesser

    (Metabolism Branch,
    Howard Hughes Medical Institute – National Institutes of Health Research Scholars Program, Bethesda, Maryland 20892, USA)

  • Holger Kohlhammer

    (Metabolism Branch,)

  • Laurence Lamy

    (Metabolism Branch,)

  • Hong Zhao

    (Metabolism Branch,)

  • Yandan Yang

    (Metabolism Branch,)

  • Weihong Xu

    (Metabolism Branch,)

  • Arthur L. Shaffer

    (Metabolism Branch,)

  • George Wright

    (Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Wenming Xiao

    (Bioinformatics and Molecular Analysis Section, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • John Powell

    (Bioinformatics and Molecular Analysis Section, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Jian-kang Jiang

    (NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA)

  • Craig J. Thomas

    (NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA)

  • Andreas Rosenwald

    (University of Würzburg)

  • German Ott

    (Robert-Bosch-Krankenhaus, and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology)

  • Hans Konrad Muller-Hermelink

    (University of Würzburg)

  • Randy D. Gascoyne

    (British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4E6)

  • Joseph M. Connors

    (British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4E6)

  • Nathalie A. Johnson

    (British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4E6)

  • Lisa M. Rimsza

    (University of Arizona, Tucson, Arizona 85724, USA
    Southwest Oncology Group, 24 Frank Lloyd Wright Drive, Ann Arbor, Michigan 48106, USA)

  • Elias Campo

    (Hospital Clinic, University of Barcelona)

  • Elaine S. Jaffe

    (Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Wyndham H. Wilson

    (Metabolism Branch,)

  • Jan Delabie

    (Pathology Clinic, Rikshospitalet University Hospital)

  • Erlend B. Smeland

    (Institute for Cancer Research, Rikshospitalet University Hospital and Center for Cancer Biomedicine, University of Oslo)

  • Richard I. Fisher

    (Southwest Oncology Group, 24 Frank Lloyd Wright Drive, Ann Arbor, Michigan 48106, USA
    James P. Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, New York 14642, USA)

  • Rita M. Braziel

    (Southwest Oncology Group, 24 Frank Lloyd Wright Drive, Ann Arbor, Michigan 48106, USA
    Oregon Health and Science University, Portland, Oregon 97239, USA)

  • Raymond R. Tubbs

    (Southwest Oncology Group, 24 Frank Lloyd Wright Drive, Ann Arbor, Michigan 48106, USA
    Cleveland Clinic Pathology and Laboratory Medicine Institute, Cleveland, Ohio 44195, USA)

  • J. R. Cook

    (Southwest Oncology Group, 24 Frank Lloyd Wright Drive, Ann Arbor, Michigan 48106, USA
    Cleveland Clinic Pathology and Laboratory Medicine Institute, Cleveland, Ohio 44195, USA)

  • Dennis D. Weisenburger

    (University of Nebraska Medical Center, Omaha, Nebraska 68198, USA)

  • Wing C. Chan

    (University of Nebraska Medical Center, Omaha, Nebraska 68198, USA)

  • Susan K. Pierce

    (Laboratory of Immunogenetics, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA)

  • Louis M. Staudt

    (Metabolism Branch,)

Abstract

B-cell receptors and lymphoma A link between B-cell-receptor (BCR) signalling and human B-cell lymphomas has been inferred from the study of immunoglobulin genes in human lymphomas and from work on mouse models, but more evidence is required to confirm an oncogenic role. New work from Davis et al. shows that chronic activation of BCR signalling is required for the survival of the ABC DLBCL subset of B-cell lymphomas. Somatic mutations in CD29A and CD79B found in these lymphomas appear to contribute to BCR activation.

Suggested Citation

  • R. Eric Davis & Vu N. Ngo & Georg Lenz & Pavel Tolar & Ryan M. Young & Paul B. Romesser & Holger Kohlhammer & Laurence Lamy & Hong Zhao & Yandan Yang & Weihong Xu & Arthur L. Shaffer & George Wright &, 2010. "Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma," Nature, Nature, vol. 463(7277), pages 88-92, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7277:d:10.1038_nature08638
    DOI: 10.1038/nature08638
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