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Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma

Author

Listed:
  • Min Guo

    (The Scripps Research Institute, BCC-379, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Yeeting E. Chong

    (The Scripps Research Institute, BCC-379, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Ryan Shapiro

    (The Scripps Research Institute, BCC-379, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Kirk Beebe

    (The Scripps Research Institute, BCC-379, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Present address: Metabolon, Inc., 800 Capitola Drive, Suite 1, Durham, North Carolina 27713, USA.)

  • Xiang-Lei Yang

    (The Scripps Research Institute, BCC-379, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Paul Schimmel

    (The Scripps Research Institute, BCC-379, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

Abstract

Editorial changes Alanyl tRNA synthetases can sometimes bind a glycine or a serine, instead of alanine. This would cause mistranslation if a 'wrong' amino acid were then transferred from the synthetase active site onto a growing polypeptide chain. Guo et al. use crystal structures, mutant enzymes and kinetic analyses to discover why the enzyme has such a promiscuous specificity, and how this problem is overcome through the evolution of the editing protein, AlaXps.

Suggested Citation

  • Min Guo & Yeeting E. Chong & Ryan Shapiro & Kirk Beebe & Xiang-Lei Yang & Paul Schimmel, 2009. "Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma," Nature, Nature, vol. 462(7274), pages 808-812, December.
    • Handle: RePEc:nat:nature:v:462:y:2009:i:7274:d:10.1038_nature08612
    DOI: 10.1038/nature08612
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