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Molecular coin slots for urea

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  • Mark A. Knepper

    (Mark A. Knepper is in the Epithelial Systems Biology Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1603, USA. knep@helix.nih.gov)

  • Joseph A. Mindell

    (Joseph A. Mindell is at the Membrane Transport Biophysics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4066, USA.)

Abstract

Membrane-bound protein channels that allow only urea to pass through are vital to the kidney's ability to conserve water. Crystal structures show that the channels select urea molecules by passing them through thin slots.

Suggested Citation

  • Mark A. Knepper & Joseph A. Mindell, 2009. "Molecular coin slots for urea," Nature, Nature, vol. 462(7274), pages 733-734, December.
    • Handle: RePEc:nat:nature:v:462:y:2009:i:7274:d:10.1038_462733a
    DOI: 10.1038/462733a
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