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HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

Author

Listed:
  • Hideyuki Yanai

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Tatsuma Ban

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan)

  • ZhiChao Wang

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Myoung Kwon Choi

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Takeshi Kawamura

    (Laboratory for System Biology and Medicine, RCAST, University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8904, Japan)

  • Hideo Negishi

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Makoto Nakasato

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Yan Lu

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Sho Hangai

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Ryuji Koshiba

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan)

  • David Savitsky

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Lorenza Ronfani

    (Faculty of Medicine, San Raffaele University, via Olgettina 58, 20132 Milan, Italy)

  • Shizuo Akira

    (Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Yamada-oka 3-1, Suita, Osaka 565-0871, Japan)

  • Marco E. Bianchi

    (Faculty of Medicine, San Raffaele University, via Olgettina 58, 20132 Milan, Italy)

  • Kenya Honda

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
    Present address: Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Yamada-oka 2-2, Suita, Osaka 565-0871, Japan.)

  • Tomohiko Tamura

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Tatsuhiko Kodama

    (Laboratory for System Biology and Medicine, RCAST, University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8904, Japan)

  • Tadatsugu Taniguchi

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan)

Abstract

HMGB protein sentinels The chromosomal HMGB (high-mobility group box) proteins HMGB1, HMGB2 and HMGB3 are shown here to be essential for all nucleic-acid receptor-mediated activation of innate immune responses. HMGBs bound to all immunogenic nucleic acids tested — whether considered ligands for Toll-like receptors or for cytosolic receptors — suggesting that they may have a physiological role as universal sentinels for intracellular nucleic acids.

Suggested Citation

  • Hideyuki Yanai & Tatsuma Ban & ZhiChao Wang & Myoung Kwon Choi & Takeshi Kawamura & Hideo Negishi & Makoto Nakasato & Yan Lu & Sho Hangai & Ryuji Koshiba & David Savitsky & Lorenza Ronfani & Shizuo Ak, 2009. "HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses," Nature, Nature, vol. 462(7269), pages 99-103, November.
    • Handle: RePEc:nat:nature:v:462:y:2009:i:7269:d:10.1038_nature08512
    DOI: 10.1038/nature08512
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