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Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

Author

Listed:
  • Ingo Bartholomäus

    (Max Planck Institute for Neurobiology)

  • Naoto Kawakami

    (Max Planck Institute for Neurobiology)

  • Francesca Odoardi

    (Max Planck Institute for Neurobiology
    Institute for Multiple Sclerosis Research, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen
    Institute for Immunology, Ludwig-Maximilians-University)

  • Christian Schläger

    (Max Planck Institute for Neurobiology
    Institute for Multiple Sclerosis Research, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen)

  • Djordje Miljkovic

    (Max Planck Institute for Neurobiology)

  • Joachim W. Ellwart

    (Institute for Experimental Hematology, Helmholtz Centre, 81377 Munich, Germany)

  • Wolfgang E. F. Klinkert

    (Max Planck Institute for Neurobiology)

  • Cassandra Flügel-Koch

    (Institute for Anatomy 2, Friedrich-Alexander-University)

  • Thomas B. Issekutz

    (Dalhousie University, Halifax, Nova Scotia B3K 6R8, Canada)

  • Hartmut Wekerle

    (Max Planck Institute for Neurobiology)

  • Alexander Flügel

    (Max Planck Institute for Neurobiology
    Institute for Multiple Sclerosis Research, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen
    Institute for Immunology, Ludwig-Maximilians-University)

Abstract

T cells in autoimmunity A two-photon fluorescence microscopy study of rats with experimental autoimmune encephalomyelitis — a model for multiple sclerosis — shows autoimmune-disease-triggering blood T cells first directly attaching and then scanning the internal surface of the spinal meningeal vasculature, sometimes crawling against the direction of blood flow. Once across the blood–brain barrier, the T cells engage with antigen-presenting phagocytes that in turn stimulate their further differentiation and tissue infiltration. The structures involved in these interactions with T cells could be potential candidate targets for therapy against autoimmune brain disease.

Suggested Citation

  • Ingo Bartholomäus & Naoto Kawakami & Francesca Odoardi & Christian Schläger & Djordje Miljkovic & Joachim W. Ellwart & Wolfgang E. F. Klinkert & Cassandra Flügel-Koch & Thomas B. Issekutz & Hartmut We, 2009. "Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions," Nature, Nature, vol. 462(7269), pages 94-98, November.
    • Handle: RePEc:nat:nature:v:462:y:2009:i:7269:d:10.1038_nature08478
    DOI: 10.1038/nature08478
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