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Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

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  • Kendle M. Maslowski

    (Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Cooperative Research Center for Asthma and Airways, Camperdown, New South Wales 2050, Australia
    St Vincent's Clinical School, University of New South Wales)

  • Angelica T. Vieira

    (Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil)

  • Aylwin Ng

    (Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA)

  • Jan Kranich

    (Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Cooperative Research Center for Asthma and Airways, Camperdown, New South Wales 2050, Australia)

  • Frederic Sierro

    (Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia)

  • Di Yu

    (Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia)

  • Heidi C. Schilter

    (Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Cooperative Research Center for Asthma and Airways, Camperdown, New South Wales 2050, Australia
    St Vincent's Clinical School, University of New South Wales)

  • Michael S. Rolph

    (Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Cooperative Research Center for Asthma and Airways, Camperdown, New South Wales 2050, Australia)

  • Fabienne Mackay

    (Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Faculty of Medicine, Monash University, Wellington Road, Clayton, Victoria 3800, Australia)

  • David Artis

    (School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • Ramnik J. Xavier

    (Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA)

  • Mauro M. Teixeira

    (Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil)

  • Charles R. Mackay

    (Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Cooperative Research Center for Asthma and Airways, Camperdown, New South Wales 2050, Australia
    St Vincent's Clinical School, University of New South Wales
    Faculty of Medicine, Monash University, Wellington Road, Clayton, Victoria 3800, Australia)

Abstract

GPR43 receptor as anti-inflammatory target Recent evidence has suggested that the products of 'friendly' intestinal microbes can help counter inflammatory disease and Type 1 diabetes in the host. Commensal bacteria in the colon are known to ferment dietary fibres to produce short-chain fatty acids, and now a study of a mouse model of colitis shows that these fatty acids down-regulate innate and inflammatory responses by stimulating the chemoattractant receptor GPR43 on neutrophils. This identifies interactions between short-chain fatty acids and GPR43 as a possible target for the manipulation of immune responses.

Suggested Citation

  • Kendle M. Maslowski & Angelica T. Vieira & Aylwin Ng & Jan Kranich & Frederic Sierro & Di Yu & Heidi C. Schilter & Michael S. Rolph & Fabienne Mackay & David Artis & Ramnik J. Xavier & Mauro M. Teixei, 2009. "Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43," Nature, Nature, vol. 461(7268), pages 1282-1286, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7268:d:10.1038_nature08530
    DOI: 10.1038/nature08530
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    Cited by:

    1. John Molloy & Katrina Allen & Fiona Collier & Mimi L. K. Tang & Alister C. Ward & Peter Vuillermin, 2013. "The Potential Link between Gut Microbiota and IgE-Mediated Food Allergy in Early Life," IJERPH, MDPI, vol. 10(12), pages 1-22, December.
    2. Todd D. Terhune & Richard C. Deth, 2018. "Aluminum Adjuvant-Containing Vaccines in the Context of the Hygiene Hypothesis: A Risk Factor for Eosinophilia and Allergy in a Genetically Susceptible Subpopulation?," IJERPH, MDPI, vol. 15(5), pages 1-16, May.
    3. Natalia Di Tommaso & Antonio Gasbarrini & Francesca Romana Ponziani, 2021. "Intestinal Barrier in Human Health and Disease," IJERPH, MDPI, vol. 18(23), pages 1-23, December.
    4. Patrick J. Dörner & Harithaa Anandakumar & Ivo Röwekamp & Facundo Fiocca Vernengo & Belén Millet Pascual-Leone & Marta Krzanowski & Josua Sellmaier & Ulrike Brüning & Raphaela Fritsche-Guenther & Lenn, 2024. "Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Mai Kugawa & Kouki Kawakami & Ryoji Kise & Carl-Mikael Suomivuori & Masaki Tsujimura & Kazuhiro Kobayashi & Asato Kojima & Wakana J. Inoue & Masahiro Fukuda & Toshiki E. Matsui & Ayami Fukunaga & Junk, 2025. "Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    6. Eunkyung Lee & Vanessa Kady & Eric Han & Kayla Montan & Marjona Normuminova & Michael J. Rovito, 2022. "Healthy Eating and Mortality among Breast Cancer Survivors: A Systematic Review and Meta-Analysis of Cohort Studies," IJERPH, MDPI, vol. 19(13), pages 1-24, June.
    7. Denisa Margină & Anca Ungurianu & Carmen Purdel & Dimitris Tsoukalas & Evangelia Sarandi & Maria Thanasoula & Fotios Tekos & Robin Mesnage & Demetrios Kouretas & Aristidis Tsatsakis, 2020. "Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors," IJERPH, MDPI, vol. 17(11), pages 1-27, June.

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