IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v461y2009i7264d10.1038_nature08436.html
   My bibliography  Save this article

Direct reprogramming of human neural stem cells by OCT4

Author

Listed:
  • Jeong Beom Kim

    (Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany)

  • Boris Greber

    (Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany)

  • Marcos J. Araúzo-Bravo

    (Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany)

  • Johann Meyer

    (Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany)

  • Kook In Park

    (BK21 Project for Medical Sciences, Yonsei University College of Medicine, 250 Seongsanno, Seodaemoon-gu, Seoul 120-752, Korea)

  • Holm Zaehres

    (Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany)

  • Hans R. Schöler

    (Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, NRW, Germany)

Abstract

Human iPS cells made simpler Earlier this year Hans Schöler's group reported that a single transcription factor, OCT4, was sufficient to reprogram mouse adult neural stem cells to pluripotency, making them capable of producing virtually any cell type in the right conditions. This was a striking simplification of the process — OCT4 was just one of four factors used in the early (2006/7) and classic work on producing iPS (induced pluripotent stem) cells. Now Schöler and colleagues show that OCT4 alone can also generate iPS cells from human neural stem cells.

Suggested Citation

  • Jeong Beom Kim & Boris Greber & Marcos J. Araúzo-Bravo & Johann Meyer & Kook In Park & Holm Zaehres & Hans R. Schöler, 2009. "Direct reprogramming of human neural stem cells by OCT4," Nature, Nature, vol. 461(7264), pages 649-653, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7264:d:10.1038_nature08436
    DOI: 10.1038/nature08436
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08436
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08436?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:461:y:2009:i:7264:d:10.1038_nature08436. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.